Sicilian centenarian offspring are more resistant to immune ageing

  • Graziella Rubino
  • Matteo Bulati
  • Anna Aiello
  • Stefano Aprile
  • Caterina Maria Gambino
  • Francesco Gervasi
  • Calogero Caruso
  • Giulia Accardi
Original Article
  • 26 Downloads

Abstract

Background

Immunosenescence constitutes a major indirect cause of morbidity and mortality in the elderly. Previous analysis of immune signatures in a cohort of centenarian offspring showed an intermediate immunophenotype between age-matched and younger controls.

Aims

To confirm and extend the previous studies performing further phenotypical analysis in centenarian offspring and controls.

Methods

Analysis of Treg cells, γδ T cells, mucosal-associated invariant T cells, and senescent immune T cells was performed in centenarian offspring and controls.

Results

We report significant differences between elderly and centenarian offspring in most of the studied subsets, showing that centenarian offspring subsets present an intermediate phenotyping between elderly and younger people.

Conclusion

The whole present data confirm and extend the previous results showing that centenarian offspring retain more youthful immunological parameters and that the exhaustion of the immune system is less evident than in elderly without centenarian parents, though further investigations are warranted.

Keywords

Ageing Centenarians Immune senescence Inflammation Flow cytometry 

Notes

Acknowledgements

The authors are grateful to all participants (as well as their legal proxies) for their great contributions.

Compliance with ethical standards

Conflict of interest

None of the authors has any conflict of interest related.

Human and animal rights

All procedures performed in this study involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. This article does not contain any study with animals performed by any of the authors.

Informed consent

Informed consent was obtained from all the participants in this study or their legal proxies.

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Graziella Rubino
    • 1
    • 2
  • Matteo Bulati
    • 2
  • Anna Aiello
    • 2
  • Stefano Aprile
    • 2
  • Caterina Maria Gambino
    • 2
  • Francesco Gervasi
    • 3
  • Calogero Caruso
    • 2
  • Giulia Accardi
    • 2
  1. 1.Department of Internal MedicineUniversity of TübingenTübingenGermany
  2. 2.Department of Pathobiology and Medical BiotechnologiesUniversity of PalermoPalermoItaly
  3. 3.Specialistic Oncology Laboratory UnitARNAS Hospitals CivicoPalermoItaly

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