No modifying effect of nutritional status on statins therapy in relation to all-cause death in older patients with coronary artery disease
Statins therapy in the secondary prevention of coronary artery disease (CAD) is associated with a lower risk of adverse cardiovascular events. However, little is known regarding the association of elderly patients with nutritional risk on statin therapy.
To investigate whether older patients with CAD who were at nutritional risk gain similar survival benefit from statins therapy as their counterparts without nutritional risk.
We conducted a retrospective hospital-based cohort study among 1705 patients with CAD who were older than 65 years of age, using coronary heart disease database from 2008 to 2012. Nutritional status of included patients was gauged using the geriatric nutritional risk index. After stratification by nutritional status, the hazard of all-cause death was compared between those with or without statins therapy.
Of the 1705 patients included in the study (mean age 72 years; 73% male), all-cause death occurred in 146 (9.2%) patients with statins use and in 33 (26.2%) patients without statins use. The rate of all-cause death was higher in patients not receiving statins irrespective of nutritional status. After adjustments for potential confounders, the HR with statins use was 0.33 (95% CI 0.20–0.55) in patients without nutritional risk and 0.47 (95% CI 0.22–1.00) in patients with nutritional risk. No interaction effect was detected between nutritional status and statins use in relation to all-cause death (P value for interaction effect 0.516).
Despite of the patient’s nutritional status, statins therapy as a secondary prevention in elderly CAD patients was associated with decreased risk of all-cause death.
KeywordsCoronary artery disease Death Elderly Nutrition Statins
This work was supported by the National Natural Science Foundation of China under Grant (numbers: 81370219 and 81400267, Beijing, China); the Supporting Project of Sichuan Provincial Department of Science and Technology under Grant (number 2014SZ0004, Sichuan, China); and the Sichuan province Science and Technology Innovation Team under Grant (number 2017TD0004, Sichuan, China).
Compliance with ethical standards
Conflict of interest
The authors report no conflicts of interest.
Research involving human participants
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
Informed consent was obtained from all individual participants included in the study.
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