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Serum γ-glutamyltranspeptidase and oxidative stress in subjectively healthy women: an association with menopausal stages

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Abstract

Background

Gamma-glutamyltransferase (γ-GT) is used as a marker of alcohol-related pathology, while γ-GT is recently considered to be an oxidative stress marker.

Aim

The present study aimed to investigate the correlation between the oxidative status and γ-GT levels, in association with menopausal stages.

Methods

In total, 252 women, who were subjectively healthy, were divided into three groups: premenopausal, perimenopausal, and postmenopausal. The circulating oxidative status was evaluated by the diacron-reactive oxygen metabolite (d-ROM) test. In addition to serum γ-GT, routine blood investigations, including lipid, glucose, and inflammatory parameters, were performed.

Results

The median γ-GT level was 17 U/L and the mean d-ROM level was 335 Carr U in all subjects. On multiple regression analysis, independent significant positive correlations were observed between d-ROM and high-sensitivity CRP levels in three groups, while there was a significant positive correlation between d-ROM and γ-GT levels only in the premenopausal group but not in the perimenopausal and postmenopausal groups.

Discussion

The significant relationship between d-ROM and γ-GT at active estrogen stage may indicate a different oxidative stress condition by memopausal stage. The reasons of this relationship should be further explored.

Conclusion

A positive relationship between d-ROM and γ-GT levels, both as known as oxidative stress-related markers, could exist in premenopausal women.

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Authors and Affiliations

  1. JT. Chen Clinic, Akasaka-Kaikan B1F, 2-13-5 Akasaka, Minato-Ku, Tokyo, 107-0052, Japan

    Jui-Tung Chen

  2. Division of Community and Family Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan

    Kazuhiko Kotani

Authors
  1. Jui-Tung Chen
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Correspondence to Jui-Tung Chen.

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Chen, JT., Kotani, K. Serum γ-glutamyltranspeptidase and oxidative stress in subjectively healthy women: an association with menopausal stages. Aging Clin Exp Res 28, 619–624 (2016). https://doi.org/10.1007/s40520-015-0460-y

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  • DOI: https://doi.org/10.1007/s40520-015-0460-y

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