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Compulsive eating behaviors in Parkinson’s disease

  • Ingrid de ChazeronEmail author
  • Franck Durif
  • Isabelle Chereau-Boudet
  • Maria Livia Fantini
  • Ana Marques
  • Philippe Derost
  • Berengere Debilly
  • Georges Brousse
  • Yves Boirie
  • Pierre Michel Llorca
Original Article
Part of the following topical collections:
  1. Food Addiction

Abstract

Purpose

Eating disorders are common in Parkinson’s disease (PD) patients and often class in Impulse control disorders, however, little is known about their phenomenology. Specific symptoms and comorbidities were described in a group of PD patients in this preliminary study.

Methods

Over a period of 6 months, 51 PD patients who experienced significant changes in eating habits following diagnosis of PD and were interviewed during regularly scheduled follow-up visits. We assessed each patient’s height and weight, impulsivity, psychological distress, current eating disorder symptoms, food addiction, food habits and craving.

Results

Among the PD patients who experienced modified dietary habits following diagnosis, few exhibited binge eating disorders (BED) full criteria (3.9%). However, 21.6% of patients experienced episodes of out-of-control eating with a large quantity of food in short time and 39.2% satisfied food addiction (FA) criteria without binge eating disorder. Food cravings more than once a week were experienced in approximately half of the population including all FA patients. Regarding comorbidities, FA PD patients present impulsive features and anxiety.

Conclusions

This study confirms the existence of FA profile in PD patients. Eating disorders even in PD are complex and have a cross-cutting criteria related to out-of-control eating, FA, and BED. The association of anxiety with PD-related food addiction, contrary to L-dopa equivalent daily dose mean score or the presence of dopamine agonists, underline the complex sustainability of the dopaminergic brainstem support. A study on their detailed prevalence in this population could be helpful to better understand unspecified feeding or eating disorder.

Clinical trial number

DR-2012-007.

Name of the registry

French Committee for the Protection of Persons (CPP) & French National Commission on Computing and Liberty (CNIL).

Level of evidence

Level V, descriptive study.

Keywords

Eating disorders Food addiction Parkinson’s disease Psychiatry 

Abbreviations

EDs

Eating disorders

BEDs

Binge eating disorders

BIS-11

Barratt impulsiveness scale

BMI

Body mass index

CE

Compulsive eating

FA

Food addiction

HADS

Hospital anxiety and depression scale

ICDs

Impulse control disorders

PD

Parkinson’s disease

LEDD

l-DOPA equivalent daily dose

MDS-UPDRS

Movement Disorders Society-Unified Parkinson Disease Rating Scale

NES

Night eating syndrome

NFA

No food addiction

QEWP-R

Questionnaire on Eating and Weight Patterns

QUIP

Questionnaire for Impulsive-Compulsive Disorders in Parkinson’s Disease

Notes

Authors’ contributions

IdC: study design, manuscript preparation and final approval of the version to be submitted. FD: clinical assessment, manuscript preparation and final approval of the version to be submitted. ICB: study design. MLF: clinical assessment. AM: clinical assessment. PD: clinical assessment. BD: clinical assessment. GB: manuscript preparation. YB: manuscript preparation and final approval of the version to be submitted. PML: study design, manuscript preparation and final approval of the version to be submitted. All authors read and approved the final manuscript.

Funding

The study was funded by a regional public grant (AOI CHU Clermont-Ferrand 2010). The funder had no role in the writing of the study protocol or in the conductance of the study.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no competing interests.

Ethics approval and consent to participate

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. The study was approved by the French Ethic Committee (Committees of Protection of Persons South-East 6). It has been qualified by Ethics Committee as an observational study. Pursuant to L.1121-1-1 and R.1121-3 of the French Public Health Code in force at the time of the research, written informed consent from participants to conduct this study was not required.

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Ingrid de Chazeron
    • 1
    Email author
  • Franck Durif
    • 2
  • Isabelle Chereau-Boudet
    • 1
  • Maria Livia Fantini
    • 2
  • Ana Marques
    • 2
  • Philippe Derost
    • 2
  • Berengere Debilly
    • 2
  • Georges Brousse
    • 1
  • Yves Boirie
    • 3
  • Pierre Michel Llorca
    • 1
  1. 1.Service de Psychiatrie BCHU Clermont-Ferrand, EA7280, Université Clermont AuvergneClermont-FerrandFrance
  2. 2.Service de neurologie ACHU Clermont-Ferrand, EA7280, Université Clermont AuvergneClermont-FerrandFrance
  3. 3.Service de nutrition cliniqueCHU Clermont-Ferrand, INRA, UMR 1019, UNH, CRNH AuvergneClermont-FerrandFrance

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