DRD2/ANKK1 TaqI A1 polymorphism associates with overconsumption of unhealthy foods and biochemical abnormalities in a Mexican population

  • Ingrid Rivera-Iñiguez
  • Arturo Panduro
  • Omar Ramos-Lopez
  • Sergio Javier Villaseñor-Bayardo
  • Sonia RomanEmail author
Original Article
Part of the following topical collections:
  1. Food and Addiction



The dopamine receptor 2/ankyrin repeat domain and content kinase 1 (DRD2/ANKK1) TaqIA polymorphism (rs1800497) has been associated with rewarding behaviors. This study aimed to investigate the association of DRD2/ANKK1 TaqIA polymorphism with the dietary intake, the intake frequency of food groups and biochemical profile in Mexican mestizo subjects.


A cross-sectional/analytical study with 276 Mexican subjects was performed. Dietary intake was assessed with a 24-h recall and a food frequency questionnaire (FFQ). An allelic discrimination assay evaluated DRD2/ANKK1 TaqIA genotypes. Anthropometric and biochemical data were evaluated.


Genotype frequencies were A1A1 (18.48%), A1A2 (45.29%) and A2A2 (36.23%). TaqI A1 allele carriers had a higher intake of carbohydrates (p = 0.038), meats (p = 0.005), fried dishes (p = 0.039), and sugars (p = 0.009). Male TaqI A1 carriers consumed more carbohydrates (p = 0.009) and meats (p = 0.018) while females consumed fewer legumes (p = 0.005). TaqI A1 carriers had glucose (p = 0.037) and triglycerides (p = 0.011) abnormalities. TaqI A1 was associated with higher risk of consumption of unhealthy foods such as fried dishes (OR 3.79, 95% CI 1.53–9.35, p = 0.002) and meats (OR 2.31, 95% CI 1.32–4.05, p = 0.003), and lower healthy foods (OR 1.89, 95% CI 1.04–3.29, p = 0.038). TaqI A1 allele was associated with risk of abnormal glucose, triglycerides, and VLDL levels (OR 2.148, 95% CI 1.068–4.322, p = 0.036; OR 1.999, 95% CI 1.194–3.348, p = 0.011; OR 2.021, 95% CI 1.203–3.392, p = 0.007), respectively.


The presence of the TaqI A1 allele in Mexicans is a genetic risk factor for detrimental dietary quality that may predispose to metabolic disturbances.

Level of evidence

Level III, case-control analytic study.


Dopamine Dopamine receptors Food behavior Obesity Dyslipidemia 



The authors acknowledge the help of the entire team at the Nutrigenetic Clinic of the Department of Molecular Biology in Medicine at the Civil Hospital of Guadalajara “Fray Antonio Alcalde”.


This study was supported by PRODEP-UNIVERSIDAD DE GUADALAJARA CA478, Guadalajara, Jalisco, Mexico (CA478).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

The study protocol was approved by the Institutional Review Board of the Civil Hospital of Guadalajara “Fray Antonio Alcalde”, Guadalajara, Jalisco, Mexico.

Informed consent

Written consent was obtained from each participant.

Supplementary material

40519_2018_596_MOESM1_ESM.docx (14 kb)
Supplementary material 1 (DOCX 13 KB)


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Copyright information

© Springer Nature Switzerland AG 2018

Authors and Affiliations

  1. 1.Department of Molecular Biology in MedicineCivil Hospital of Guadalajara, “Fray Antonio Alcalde”GuadalajaraMexico
  2. 2.Health Sciences CenterUniversity of GuadalajaraGuadalajaraMexico
  3. 3.Psychiatry ServiceCivil Hospital of Guadalajara, “Fray Antonio Alcalde”GuadalajaraMexico

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