Can body temperature dysregulation explain the co-occurrence between overweight/obesity, sleep impairment, late-night eating, and a sedentary lifestyle?
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Overweight/obesity, sleep disturbance, night eating, and a sedentary lifestyle are common co-occurring problems. There is a tendency for them to co-occur together more often than they occur alone. In some cases, there is clarity as to the time course and evolution of the phenomena. However, specific mechanism(s) that are proposed to explain a single co-occurrence cannot fully explain the more generalized tendency to develop concurrent symptoms and/or disorders after developing one of the phenomena. Nor is there a clinical theory with any utility in explaining the development of co-occurring symptoms, disorders and behaviour and the mechanism(s) by which they occur. Thus, we propose a specific mechanism—dysregulation of core body temperature (CBT) that interferes with sleep onset—to explain the development of the concurrences.
A detailed review of the literature related to CBT and the phenomena that can alter CBT or are altered by CBT is provided.
Overweight/obesity, sleep disturbance and certain behaviour (e.g. late-night eating, sedentarism) were linked to elevated CBT, especially an elevated nocturnal CBT. A number of existing therapies including drugs (e.g. antidepressants), behavioural therapies (e.g. sleep restriction therapy) and bright light therapy can also reduce CBT.
An elevation in nocturnal CBT that interferes with sleep onset can parsimoniously explain the development and perpetuation of common co-occurring symptoms, disorders and behaviour including overweight/obesity, sleep disturbance, late-night eating, and sedentarism. Nonetheless, a significant correlation between CBT and the above symptoms, disorders and behaviour does not necessarily imply causation. Thus, statistical and methodological issues of relevance to this enquiry are discussed including the likely presence of autocorrelation.
Level of evidence
Level V, narrative review.
KeywordsComorbidity Co-occurrence Overweight/obesity Sleep disturbance Core body temperature Late-night eating Sedentarism
Compliance with ethical standards
Conflict of interest
On behalf of all authors, there is no conflict of interest at all in regards to the submitted publication. That is, no author has a financial or personal relationship with a third party whose interests could be positively or negatively influenced by the article’s content.
This research paper was not supported by a funding source.
Human and animal participants
This article does not contain any studies with human participants or involving animals performed by any of the authors.
- 7.Degenhardt L, Hall W, Lynskey M (2003) What is comorbidity and why does it occur? In: Teesson M, Proudfoot H (eds) Comorbid mental disorders and substance use disorders: epidemiology, prevention and treatment. National Drug and Alcohol Research Centre, Sydney, pp 10–25Google Scholar
- 11.Maser JD, Cloninger CR (1990) Cormorbidity of mood and anxiety disorders. American Psychiatric, Washington, DCGoogle Scholar
- 24.Rand CSW, Macgregor AMC, Stunkard AJ (1997) The night eating syndrome in the general population and among postoperative obesity surgery patients. Int J Eat Disord 22(1):65–69. doi: 10.1002/(SICI)1098-108X(199707)22:1<65::AID-EAT8>3.0.CO;2-0 CrossRefPubMedGoogle Scholar
- 33.Gillberg M, Åkerstedt T (1982) Body temperature and sleep at different times of day. Sleep J Sleep Res Sleep Med 5(4):378–388Google Scholar
- 48.Miller CB, Kyle SD, Gordon CJ, Espie CA, Grunstein RR, Mullins AE, Postnova S, Bartlett DJ (2015) Physiological markers of arousal change with psychological treatment for insomnia: a preliminary investigation. PloS One 10(12):e0145317. doi: 10.1371/journal.pone.0145317 CrossRefPubMedPubMedCentralGoogle Scholar
- 58.Calfas KJ, Sallis JF, Nichols JF, Sarkin JA, Johnson MF, Caparosa S, Thompson S, Gehrman CA, Alcaraz JE (2000) Project GRAD: two-year outcomes of a randomized controlled physical activity intervention among young adults. Am J Prev Med 18(1):28–37. doi: 10.1016/S0749-3797(99)00117-8 CrossRefPubMedGoogle Scholar
- 68.von Loeffelholz C (2014) The role of non-exercise activity thermogenesis in human obesity. MDText.com, South DartmouthGoogle Scholar
- 92.Pigeau R, Naitoh P, Buguet A, McCann C, Baranski J, Taylor M, Thompson M, Mack I (1995) Modafinil, d-amphetamine and placebo during 64 h of sustained mental work. I. Effects on mood, fatigue, cognitive performance and body temperature. J Sleep Res 4(4):212–228. doi: 10.1111/j.1365-2869.1995.tb00172.x CrossRefPubMedGoogle Scholar
- 98.Aikens JE, Reinecke MA, Pliskin NH, Fischer JS, Wiebe JS, McCracken LM, Taylor JL (1999) Assessing depressive symptoms in multiple sclerosis: is it necessary to omit items from the original Beck Depression Inventory? J Behav Med 22(2):127–142. doi: 10.1023/A:1018731415172 CrossRefPubMedGoogle Scholar
- 106.Ballesio A, Aquino MRJV, Feige B, Johann AF, Kyle SD, Spiegelhalder K, Lombardo C, Rücker G, Riemann D, Baglioni C (2017) The effectiveness of behavioural and cognitive behavioural therapies for insomnia on depressive and fatigue symptoms: a systematic review and network meta-analysis. Sleep Med Rev. doi: 10.1016/j.smrv.2017.01.006 CrossRefPubMedGoogle Scholar