Adiponectin gene variants and abdominal obesity in an Iranian population
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Waist-to-height ratio (WHtR) can be effective for the diagnosis of abdominal obesity and the risk of type 2 diabetes. The role of genetic factors in the development of obesity has been broadly recognized. Adiponectin’s level is inversely correlated with body fat percentage and is reduced in obesity and type 2 diabetes. The aim of this study is to investigate the association between WHtR and adiponectin gene polymorphisms in Iranian population.
This study was conducted on 610 subjects from two Iranian populations. Anthropometric characteristics were measured by routine methods. Blood samples were collected in tubes (3–5 mL) containing EDTA and were stored at 20 °C. After DNA extraction, genotyping was performed using PCR–RFLP technique.
There were statistically significant differences in genotype frequencies of −11391 G/A in centrally obese (WHtR >0.5) and noncentrally obese (WHtR ≤0.5) subjects (P value <0.044). In the former, the frequencies of GG and GA + AA genotypes were 89.4 and 10.6 %, respectively, while the frequencies of GG and GA + AA genotypes were 95.9 and 4.1 %, respectively, in noncentrally obese subjects.
The frequency of GG genotype was significantly increased in subjects with WHtR >0.5 compared to the other group. After adjustment for diabetes, abdominal obesity was significantly associated with the −11391 G/A polymorphism.
KeywordsObesity Adiponectin Diabetes Abdominal obesity Polymorphism Waist-to-height ratio Metabolic syndrome
Body mass index
Implementation of this study was sponsored by Tehran University of Medical Sciences (Endocrinology and Metabolism Research Center).
Compliance with ethical standards
Conflict of interest
The authors declare that they have no competing interests.
The study has been approved by ethical committee of Tehran University of Medical Sciences.
Informed consents have been obtained from all patients participating in the study.
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