Multidisciplinary Treatment for Individuals at Clinical High Risk of Developing Psychosis
One of the goals of identifying youth identified, based on clinical symptoms, as being at risk for developing psychosis, is to find ways to prevent or even delay the onset of the illness. Over the past 20 years, relatively few randomized control trials (RCTs), including both pharmacological and psychosocial interventions, have been conducted and often with inconsistent results. Several recent meta-analyses suggest that there are few treatments if any that might be effective and that no one treatment is seen as being more effective than any other treatment. This review aims to examine the existing RCTs and to critically review recent meta-analyses.
Individuals at clinical high risk for psychosis are a heterogeneous group. Unfortunately, many interventions have not been specifically designed to address the outcome being assessed nor have participants been specifically selected for that treatment.
The trials completed to date and the recent systematic reviews should be seen positively and used to guide the design of future trials to ensure that the right interventions are offered to the right people at the right time.
KeywordsPsychosis Prodrome Clinical trials Clinical high risk Meta-analyses Treatment
Preparation of this article was supported by the National Institute of Mental Health Grant MH105178 to Jean Addington. Olga Santesteban-Echarri is supported by a Canadian Institutes of Health Research post-doctoral scholarship and Dan Devoe by an Alberta Innovates Graduate Scholarship.
Compliance with ethical standards
Conflict of interest
Jean Addington declares no conflict of interest. Daniel Devoe declares no conflict of interest. Olga Santesteban-Echarri declares no conflict of interest.
Human and animal rights and informed consent
All reported studies/experiments with human or animal subjects performed by the authors have been previously published and complied with all applicable ethical standards (including the Helsinki declaration and its amendments, institutional/national research committee standards, and international/national/institutional guidelines).
References and Recommended Reading
Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance
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