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Current Treatment Options in Psychiatry

, Volume 6, Issue 2, pp 154–163 | Cite as

New-generation Antipsychotics and Cardiovascular Risk

  • Aishwarya K. Rajagopalan
  • William K. Bache
  • Serena Z. Chen
  • Ermal Bojdani
  • Kevin J. LiEmail author
Schizophrenia and Other Psychotic Disorders (J Csernansky, Section Editor)
  • 9 Downloads
Part of the following topical collections:
  1. Topical Collection on Schizophrenia and Other Psychotic Disorders

Abstract

Purpose of Review

To critically review the current landscape of literature on cardiotoxicity of “new-generation antipsychotics,” defined as those approved by the Food and Drug Administration in the last 10 years.

Recent Findings

There is a paucity of data regarding the cardiovascular risks of these medications. Based on the investigations that have been published, iloperidone appears to be the greatest risk of corrected QT prolongation followed by asenapine whereas lurasidone, cariprazine, and brexpiprazole were not found to have significant effects on corrected QT. However, the evidence was low quality. In terms of metabolic effects, asenapine, iloperidone, cariprazine, and brexpiprazole all had mild to moderate effects whereas lurasidone had no significant effects observed.

Summary

Further investigation is warranted for all of these medications to better understand their cardiovascular effects.

Keywords

Antipsychotics Cardiotoxicity Brexpiprazole Cariprazine Asenapine Iloperidone 

Notes

Acknowledgments

We would like to acknowledge Elaine Alligood for her assistance in literature search and article access.

Compliance with Ethical Standards

Conflict of Interest

Aishwarya K. Rajagopalan, William K. Bache, Serena Z. Chen, Ermal Bojdani, and Kevin J. Li declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

References and Recommended Reading

Papers of particular interest, published recently, have been highlighted as: • Of importance

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Copyright information

© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2019

Authors and Affiliations

  • Aishwarya K. Rajagopalan
    • 1
    • 2
    • 3
  • William K. Bache
    • 1
    • 2
    • 3
  • Serena Z. Chen
    • 1
    • 2
    • 3
  • Ermal Bojdani
    • 1
    • 2
    • 3
  • Kevin J. Li
    • 1
    • 2
    • 3
    Email author
  1. 1.Department of Veterans AffairsBrocktonUSA
  2. 2.Harvard South Shore Psychiatry Residency Training ProgramBrocktonUSA
  3. 3.Harvard Medical SchoolBostonUSA

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