Nutritional Status Influencing Orofacial Developmental Anomalies

  • Ashish ShresthaEmail author
  • Chandramani B. More
  • Shashi Keshwar
  • Bijayata Shrestha
  • Toniya Raut
Oral Disease and Nutrition (F Nishimura, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Oral Disease and Nutrition


Purpose of Review

Developmental anomalies affecting orofacial region are not that uncommon. Genetic factors play an important role in developmental anomalies of the orofacial region. However, the role of other factors including nutrition cannot be disregarded. This review focuses on the current literature regarding the role of nutrition in the normal development and various developmental anomalies associated with nutritional deficiency.

Recent Findings

Neural crest cells have an enigmatic role in the development of orofacial region, and there are evidences to support the importance of nutrition in its differentiation. Studies have been conducted to document the role of some nutrients in the development and growth; despite that there are many, the roles of which are not yet established. Most of the studies are focused on orofacial clefts but very sparse in other orofacial anomalies.


The impact of malnutrition can also be considered a key factor in developmental anomalies of orofacial region. There is an increasing need of awareness regarding balanced nutrition for the mother and developing child. Although role of nutrition in normal development is established the role of many nutrients are still not established which highlights the need for further research.


Developmental anomalies Malnutrition Neural crest cell Nutritional deficiency Orofacial 


Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Ashish Shrestha
    • 1
    Email author
  • Chandramani B. More
    • 2
  • Shashi Keshwar
    • 1
  • Bijayata Shrestha
    • 3
  • Toniya Raut
    • 1
  1. 1.Department of Oral Pathology, College of Dental SurgeryBP Koirala Institute of Health SciencesDharan- 18Nepal
  2. 2.Department of Oral Medicine and Maxillofacial Radiology, K. M. Shah Dental College and HospitalSumandeep VidyapeethVadodaraIndia
  3. 3.Department of Oral PathologyGandaki Medical CollegePokharaNepal

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