Current Oral Health Reports

, Volume 5, Issue 4, pp 304–316 | Cite as

Scaffold Materials and Dental Stem Cells in Dental Tissue Regeneration

  • Susanne Proksch
  • Kerstin M. GallerEmail author
Dental Stem Cells in Tissue Regeneration (F Setzer, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Dental Stem Cells in Tissue Regeneration


Purpose of Review

Tissue engineering, as a multidisciplinary approach, is a research topic in medicine, but also in dentistry, to build structures, such as enamel, the dentin-pulp complex, the periodontium, or even whole teeth. The purpose of this review is to describe the latest developments in dental tissue engineering, where some of them will change our treatment concepts in dentistry in the near future, and to discuss hurdles and challenges.

Recent Findings

Sophisticated scaffold materials for dental tissue engineering can be fabricated today. No longer only bioinert, but tailor-made for specific applications, biomimetic and bioactive through biochemical and physical cues, growth and differentiation factors, they are able to elicit specific cellular responses, and thus control new tissue formation. Dental stem cells can not only be isolated from various sources but used for their paracrine activity, synergistic effects with epithelial cells exploited, and their behavior modulated by epigenetics. A better understanding of the interplay between cell differentiation and immune and inflammatory stimuli is crucial for the regeneration of tissues, which are constantly confronted with microorganisms. Examples for recent developments include commercially available products for the treatment of initial enamel lesions, a pilot clinical study for dentin-pulp complex regeneration, preclinical trials using cell sheets for periodontal regeneration, and the investigation of various cell sources for whole-tooth engineering.


This review highlights recent advances in dental tissue engineering, discusses some of the shortcomings and describes visions and future challenges.


Stem cells (MeSH ID: D013234) Tissue engineering (MeSH ID: D023822) Regeneration (MeSH ID: D012038) 


Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflicts of interest.

Human and Animal Rights and Informed Consent

All reported studies/experiments with human or animal subjects performed by the authors have been previously published and complied with all applicable ethical standards (including the Helsinki declaration and its amendments, institutional/national research committee standards, and international/national/institutional guidelines).


Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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© Springer Nature Switzerland AG 2018

Authors and Affiliations

  1. 1.G.E.R.N. Tissue Replacement, Regeneration & Neogenesis, Department of Operative Dentistry and PeriodontologyMedical Center - University of Freiburg, Faculty of Medicine, Albert-Ludwigs-University of FreiburgFreiburgGermany
  2. 2.Department of Conservative Dentistry and PeriodontologyUniversity Hospital RegensburgRegensburgGermany

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