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Application of Stem Cells for Bone Regeneration in Critical-Sized Defects

  • Shuying Yang
  • Brian P. Ford
  • Zahra Chinipardaz
  • Justin Kirkwood
Dental Stem Cells in Tissue Regeneration (F Setzer, Section Editor)
  • 7 Downloads
Part of the following topical collections:
  1. Topical Collection on Dental Stem Cells in Tissue Regeneration

Abstract

Purpose of Review

To discuss tissue bioengineering for critical-sized bone defects. To review the current stem cells that are in use and to describe the importance of an animal model for studying critical-sized bone defects.

Recent Findings

Bone marrow mesenchymal stem cells (MSCs) are well investigated. Recently, other sources of MSCs have been identified and studied in critical-sized bone defects. As for animal models, several have been used to evaluate the use of stem cells in promoting regeneration in critical-sized bone defects. This review specifically focuses on one of the most widely used and accepted models, the rodent calvarium.

Summary

Stem cell therapy is promising for bone regeneration, especially for critical-sized bone defects. Additional studies are needed to better understand both the properties and mechanisms of the different types of stem cells, and to develop animal models that mimic human biology.

Keywords

Critical-sized bone defects Bone regeneration Stem cells Mesenchymal stem cells Bone morphogenic protein BMP 

Notes

Compliance with Ethical Standards

Conflict of Interest

All authors declare no conflicts of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major Importance

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Copyright information

© Springer Nature Switzerland AG 2018

Authors and Affiliations

  • Shuying Yang
    • 1
  • Brian P. Ford
    • 2
  • Zahra Chinipardaz
    • 3
  • Justin Kirkwood
    • 4
  1. 1.Department of Anatomy & Cell Biology, School of Dental MedicineUniversity of PennsylvaniaPhiladelphiaUSA
  2. 2.Department of Oral and Maxillofacial Surgery and Pharmacology, School of Dental MedicineUniversity of PennsylvaniaPhiladelphiaUSA
  3. 3.Department of Periodontics, School of Dental MedicineUniversity of PennsylvaniaPhiladelphiaUSA
  4. 4.School of Dental MedicineUniversity of PennsylvaniaPhiladelphiaUSA

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