Current Oral Health Reports

, Volume 4, Issue 4, pp 271–277 | Cite as

Proteomics of Periodontal Pocket

  • Dimitra SakellariEmail author
Epidemiology (M Laine, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Epidemiology


Purpose of Review

This study aims to present and evaluate the findings of the literature referring to proteomic analysis of the periodontal pocket aimed to identify potential biomarkers for periodontal disease.

Recent Findings

A comprehensive examination of data from “shotgun” proteomic analysis has shown that a number of human proteins, previously not extensively investigated in the literature, have emerged as new candidates. Proteins relevant to various biological functions such as actin, profilin, hemoglobin, plastins, alpha-amylase, matrix metalloproteinases, keratins, histones, annexins, antimicrobial peptides including histatins, S-100A9, cathelicidin-related peptide-37 (LL-37), human neutrophil peptides (HNP)-1, -2, and -3, statherin, and cystatins are commonly identified in gingival crevicular fluid (GCF) by proteomic analysis and are upregulated in periodontal disease and therefore could serve as biomarkers.


Proteomic analysis has provided a new insight into the search for biomarkers of periodontal disease presence, progression, prognosis, and endpoints of treatment. Data derived should be validated by larger scale studies, including significant subject samples. These second-stage studies should focus on evaluating the importance of these proposed new biomarkers using standardized procedures.


Proteomic analysis Gingival crevicular fluid Biomarkers 


Compliance with Ethical Standards

Conflict of Interest

The author declares that he has no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


Papers of particular interest, published recently, have been highlighted as: • Of importance

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© Springer International Publishing AG 2017

Authors and Affiliations

  1. 1.Department of Preventive Dentistry, Periodontology and Implant Biology, Dental SchoolAristotle University of ThessalonikiThessalonikiGreece

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