Functional Salivary Gland Regenerative Therapy for Oral Health
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Salivary glands maintain oral health and homeostasis via functional interactions with many organs, including the teeth and the tongue. Dysfunction of salivary glands causes many problems, such as dental caries, bacterial infection, and swallowing dysfunction. Current regenerative therapy for salivary gland tissue repair and whole salivary gland replacement is currently a novel therapeutic concept that may result in full recovery of salivary gland function. The salivary glands arise from reciprocal epithelial and mesenchymal interactions. We developed a novel three-dimensional cell manipulation method that can reproduce organogenesis via the epithelial-mesenchymal interaction. The bioengineered salivary glands develop correct structure and successfully secrete saliva into the oral cavity via reestablishment of the afferent-efferent neural network. The bioengineered salivary glands also improve dry mouth symptoms, such as bacterial infections and swallowing dysfunction. This review summarizes recent findings and technological advances in salivary gland regenerative therapy.
KeywordsSalivary gland regeneration Bioengineered salivary gland germ Epithelial-mesenchymal interaction Saliva Organ germ method
This work was partially supported by a Grant-in-Aid for KIBAN (A) from the Ministry of Education, Culture, Sports and Technology (no. 25242041). This work was also partially supported by Organ Technologies Inc.
Compliance with Ethical Standards
Conflict of Interest
M. Ogawa declares that he has no conflict of interest. T. Tsuji reports a Grant-in-Aid for KIBAN (A) from the Ministry of Education, Culture, Sports, and Technology (no. 25242041) and a grant from Organ Technologies Inc.
Human and Animal Rights and Informed Consent
This article does not contain any studies with human or animal subjects performed by any of the authors.
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