Current Oral Health Reports

, Volume 3, Issue 4, pp 337–346 | Cite as

The Potential Impact of Essential Nutrients Vitamins C and D upon Periodontal Disease Pathogenesis and Therapeutic Outcomes

  • Gareth R BrockEmail author
  • Iain L C Chapple
Epidemiology (M Laine, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Epidemiology


Diet has powerful effects upon inflammatory status, arguably as strong or stronger than microbial plaque. Despite a relationship between diet and periodontal inflammatory markers being established over 30 years ago, it is only recently that the mechanisms underpinning these effects have begun to be examined in detail. Following an analysis of the evidence base in 2011, this review focuses upon the most contemporaneous evidence relating specifically to the micronutrient vitamins C and D and their potential impact upon periodontal disease pathogenesis and/or therapeutic outcomes. The authors bring together both epidemiological and laboratory data and aim to outline avenues for potential studies given the limited number of larger well-conducted clinical interventional trials completed to date.


Periodontitis Micronutrients Dietary supplements Vitamin C Ascorbic acid Vitamin D 


Compliance with Ethical Standards

Conflict of Interest

Gareth R. Brock declares that he has no conflict of interest.

Iain L. C. Chapple reports grants from NSA LLC outside of the submitted work.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


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Copyright information

© Springer International Publishing AG 2016

Authors and Affiliations

  1. 1.Division of Dentistry, School of Medical Sciences, Faculty of Biology, Medicine and HealthThe University of ManchesterManchesterUK
  2. 2.School of Dentistry, Institute of Clinical Sciences, College of Medical & Dental SciencesThe University of irminghamBirminghamUK

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