Current Oral Health Reports

, Volume 3, Issue 2, pp 124–128 | Cite as

The Dental Drug Delivery System for Prevention of Dental Caries

  • Nobuhiro HanadaEmail author
Cariology (J Tagami, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Cariology


A new therapy for the management of early caries lesions and caries prevention was established for clinical use. This therapy was named the Dental Drug Delivery System (3DS), and its effectiveness was confirmed by clinical evaluations. The 3DS method involves the application of either antimicrobial drugs or fluoride gels, with individual trays at the chair-side and also for home care program. By using the individual trays, only the cariogenic bacteria “Streptococcus mutans” that adheres to the tooth surface is controlled without changing the core composition of oral microflora. Therefore, we recommend the use of this method in dental clinics for caries management. The 3DS method should be used especially by pregnant women and mothers raising small children because children most often receive the S. mutans from their mothers via saliva. Patients with dental implants also should be treated by 3DS in order to prevent peri-implantitis. Perioperative patients and bed-ridden people who find it physically challenging to take care of their teeth would also benefit from the 3DS. Patients with severe halitosis are also candidates for 3DS treatment. The scientific rationale of 3DS and the clinical procedure involved are introduced in this article.


Dental caries Caries assessment Dental Drug Delivery System 3DS Streptococcus mutans 



This work was supported by JSPS KAKENHI Grant Number 15K15777.

Compliance with Ethical Standards

Conflict of Interest

Nobuhiro Hanada reports grants from the Japanese government during the conduct of study.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


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Copyright information

© Springer International Publishing AG 2016

Authors and Affiliations

  1. 1.Department of Translational Research, School of Dental MedicineTsurumi UniversityYokohamaJapan

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