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Current Oral Health Reports

, Volume 3, Issue 1, pp 56–63 | Cite as

What Are We Learning and What Can We Learn from the Human Oral Microbiome Project?

  • Benjamin Cross
  • Roberta C. Faustoferri
  • Robert G. QuiveyJr.Email author
Microbiology (M Klein, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Microbiology

Abstract

Extraordinary technological advances in DNA sequencing have greatly accelerated our ability to identify bacteria, at the species level, present in clinical samples taken from the human mouth. In addition, mass spectrometry has evolved such that oral samples can be analyzed for protein and metabolic products, providing insight into bacterial interaction with their human hosts in the maintenance of oral health or the onset of disease. The ability to cost-effectively determine the DNA sequence of individuals, accompanied by their unique microbiome, heralds the advent of personalized dental medicine.

Keywords

Microbiomes Oral health Oral disease Caries Periodontal disease Oral cancer 

Notes

Acknowledgments

This work was supported by the Training Program in Oral Sciences, NIH/NIDCR T90 DE021985 (B. C.), NIH/NIDCR DE013683, and DE017157 (R.G.Q.).

Compliance with Ethical Standards

Conflict of Interest

Benjamin Cross, Roberta C. Faustoferri, and Robert G. Quivey, Jr. declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

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Copyright information

© Springer International Publishing AG 2016

Authors and Affiliations

  • Benjamin Cross
    • 1
  • Roberta C. Faustoferri
    • 1
  • Robert G. QuiveyJr.
    • 1
    Email author
  1. 1.Eastman Institute for Oral Health, Center for Oral BiologyUniversity of Rochester School of Medicine and DentistryRochesterUSA

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