A Small Green Red-Ox Carries a Bright Medical Future for Sub-Saharan Africa
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Purpose of Review
Redox-related diseases are prevalent globally. Given the cost of allopathic medicines, “green preparations” are often relied on in economically developing countries. This review sought to identify medicinal plants of sub-Saharan Africa which have scientifically validated antioxidant properties, the compounds responsible for these properties, and to highlight the role of nanosizing of such plant materials in the medical future for the region.
Eighteen plants (from 13 families) with reported antioxidant properties were identified. The Euphorbiaceae (3 plants) and Capparaceae (2 plants) were the most represented families. Most of the plants were reported to be used in folk medicine for the treatment of infections and inflammation, and water and methanol were the most widely used solvents for preparing the bioactive extracts. In vitro studies (13 cases) predominated. Forty-six different bioactive compounds were reported in the 18 plants identified. Catechin/epicatechin (13 plants), gallic acid (7 plants), caffeic acid, chlorogenic acid, and vitexin/isovitexin (5 plants each) were the most widely reported antioxidant phytochemicals. Given that synergism can occur to enhance the antioxidant activities of phytochemicals, nanosizing the plant leaves identified may open new vistas of opportunities in the development of redox active green pharmaceuticals.
Given the abundance of antioxidant phenolics in the plants of sub-Saharan Africa, and the challenges of solvent extraction techniques (with respect to upscaling), nanosizing presents an eco-friendly means of sustainably exploiting these plant resources for medicinal purposes. Therefore, it appears that “a small green red-ox carries a bright medical future for sub-Saharan Africa.”
KeywordsAntioxidants Nanosizing Phytochemicals Plant leaves Redox Sub-Saharan Africa
The authors acknowledge the support of their respective Universities: The Alex Ekwueme Federal University, Ndufu-Alike, Ebonyi State, Nigeria; the Michael Okpara University of Agriculture, Umudike, Abia State, Nigeria; the Cranfield University, UK; the University of Saarland, Germany; and the University of Ottawa, Canada. CJ thanks the NutRedOx and Academics International networks for their support. CECCE thanks the DAAD for a 2018 research stays fellowship.
Conception, CECCE and CJ; literature search and data mining, ICO and CA; structures, ICO; figures, CECCE; table, CA and CECCE; preparation of initial draft of manuscript, CA, IIE, and CECCE; correction of draft for intellectual content, CCU and CJ; manuscript revision after peer-review, CCU and CECCE. All authors read and approved the final version of the manuscript.
Compliance with Ethical Standards
Ethical standards were complied with in the preparation of the manuscript.
Conflict of Interest
The authors have no real or perceived conflict of interest to declare.
Human and Animal Rights and Informed Consent
This article does not contain any studies with human or animal subjects, and as such no rights could be violated and consent was not necessary.
- 1.Kerksick CM, Zuhl M. Mechanisms of oxidative damage and their impact on contracting muscle. In: Antioxidants in sport nutrition. Boca Raton: CRC Press; 2015. p. 1–16.Google Scholar
- 2.Kumar V, Abbas AK, Aster JC. Robbins basic pathology e-book: Elsevier Health Sciences; 2017.Google Scholar
- 10.Powers SK, Kavazis AN, McClung JM. Oxidative stress and disuse muscle atrophy. J Appl Physiol. 2007;102:2389–2397.Google Scholar
- 24.Perrotta I, Aquila S. The role of oxidative stress and autophagy in atherosclerosis. Oxid Med Cell Longev. 2015; Article ID 130315, 10 pages https://doi.org/10.1155/2015/130315
- 32.Ahmad P, et al. Jasmonates: multifunctional roles in stress tolerance. Front Plant Sci. 2016;7:813.Google Scholar
- 38.Iloki-Assanga SB, Lewis-Luján LM, Lara-Espinoza CL, Gil-Salido AA, Fernandez-Angulo D, Rubio-Pino JL, et al. Solvent effects on phytochemical constituent profiles and antioxidant activities, using four different extraction formulations for analysis of Bucida buceras L. and Phoradendron californicum. BMC Research Notes. 2015;8:396.CrossRefGoogle Scholar
- 41.Jdey A. Anti-aging activities of extracts from Tunisian medicinal halophytes and their aromatic constituents. EXCLI J. 2017;16:755–69.Google Scholar
- 42.Samout N, Bouzenna H, Ettaya A, Elfeki A, Hfaiedh N. Antihypercholesterolemic effect of Cleome Arabica L on high cholesterol diet induced damage in rats. EXCLI J. 2015;14:791–800.Google Scholar
- 49.Braca A, Sinisgalli C, de Leo M, Muscatello B, Cioni PL, Milella L, et al. Phytochemical profile, antioxidant and antidiabetic activities of Adansonia digitata L. (Baobab) from Mali, as a source of health-promoting compounds. Molecules. 2018;23:3104. https://doi.org/10.3390/molecules23123104.CrossRefGoogle Scholar
- 50.Ohikhena FU, Wintola OA, Afolayan AJ. Quantitative phytochemical constituents and antioxidant activities of the mistletoe, Phragmanthera capitata (Sprengel) Balle extracted with different solvents. Pharm Res. 2018;10(1):16–23.Google Scholar
- 56.Hanafy A, et al. Evaluation of hepatoprotective activity of Adansonia digitata extract on acetaminophen-induced hepatotoxicity in rats. Evid-Based Compl Alt. 2016; ID 4579149, https://doi.org/10.1155/2016/4579149.