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Electrochemical Potential-Biological Activity Relationships of Cyclic Sulfur-Containing Molecules Against Steinernema feltiae, Botrytis cinerea, and Neuro 2a Cell Line

  • Khairan KhairanEmail author
  • Lalla Aïcha Ba
  • Torsten Burkholz
  • Michaela Leroch
  • Matthias Hahn
  • Tanya Schwab
  • Markus Klotz
  • Karl-Herbert Schaefer
  • Claus Jacob
Redox Modulators (C Jacob, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Redox Modulators

Abstract

Purpose of Review

This article provides a brief overview of electrochemical potential-biological activity relationships of natural and synthetic cyclic sulfur-containing molecules against Steinernema feltiae, Botrytis cinerea, and Neuro 2a cell line (from murine neuroblastoma).

Recent Findings

This article finds natural cyclic sulfur-containing molecules and their synthetic analogues were more reducing than glutathione (GSH) and therefore apparently did not react with GSH. The nematicidal assay indicated that cyclic disulfide compound of 1 (3-vinyl-4H-1,2-dithiin, 1,2-VDT) was more active against Steinernema feltiae with the LD50 value 151.93 ± 1.3 μM, while dithiole thione group compounds showed moderate activity against this nematode. The article also finds compound 7 (3H-1,2-dithiole-3-thione or dithiolethione, DT) has a strong activity against all different strains of Botrytis cinerea in the range concentration of 0.1–0.5 mM. This article also finds that compounds 3 (1,2-dithiane, 1,2-DT), 4 (1,5-dithiacyclooctane, 1,5-DTCO), and 7 (3H-1,2-dithiole-3-thione or dithiolethione, DT) possess some moderate activity on Neuro 2a cell lines.

Summary

Antinematode, antifungal, and anticancer activity of cyclic sulfur-containing molecules indicated that they could be promising candidates for “green pesticides” or phytoprotectans and for cancer prevention.

Keywords

Garlic Allium sativum Cyclic sulfur-containing molecules Steinernema feltiae Botrytis cinerea Neuro 2a cell lines 

Notes

Compliance with Ethical Standards

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

Open Access

This article is distributed under the terms of the Creative Commons Attribution 4.0 International Lisence (http://creativecommons.org/licences /by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons lisences, and indicate if changes were made.

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Khairan Khairan
    • 1
    • 2
    Email author
  • Lalla Aïcha Ba
    • 3
  • Torsten Burkholz
    • 4
  • Michaela Leroch
    • 5
  • Matthias Hahn
    • 5
  • Tanya Schwab
    • 6
  • Markus Klotz
    • 6
  • Karl-Herbert Schaefer
    • 6
  • Claus Jacob
    • 7
  1. 1.Department of PharmacyUniversitas Syiah KualaBanda AcehIndonesia
  2. 2.Herbal Medicinal Research CentreUniversitas Syiah KualaBanda AcehIndonesia
  3. 3.Laboratoire d’Ingénierie Moléculaire et Biochimie Pharmacologique, Institut Jean BarriolUniversité Paul Verlaine-MetzMetzFrance
  4. 4.Department of Applied Materials EngineeringInstitute of Air Handling and Refrigeration (ILK)DresdenGermany
  5. 5.Department of BiologyUniversity of KaiserslauternKaiserslauternGermany
  6. 6.Department of Microsystems TechniqueUniversity of Applied Sciences, FH-KaiserslauternStandort-ZweibrueckenGermany
  7. 7.School of PharmacyUniversitaet des SaarlandesSaarbrueckenGermany

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