The Role of Statins in the Management of Heart Failure with Preserved Ejection Fraction

  • Stelina AlkagietEmail author
  • George Giannakoulas
  • Apostolos I. Hatzitolios
  • Konstantinos Tziomalos
Cardiovascular Pharmacology (J Ndisang, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Cardiovascular Pharmacology


Purpose of Review

To discuss the current evidence regarding the role of statins in heart failure with preserved ejection fraction (HFpEF).

Recent Findings

HFpEF is a heterogeneous clinical syndrome with numerous contributors to its pathophysiology, including inflammation, arterial stiffness, and dysfunction of the autonomic nervous system. The management of HFpEF is currently symptomatic whereas agents that improve the survival of patients with HF with reduced ejection fraction, including beta-blockers, inhibitors of renin angiotensin system, and aldosterone antagonists have showed no effect on the outcome of HFpEF. On the other hand, preliminary data suggest that statins might reduce the risk of hospitalization and improve the survival of patients with HFpEF. The pleiotropic actions of these agents, particularly their effects on left ventricular function and structure and their antiinflammatory and vasoprotective actions, appear to be implicated in the improved survival of patients with HFpEF treated with statins.


Given the rising prevalence of HFpEF and the lack of treatments that affect the cardiovascular morbidity and mortality of this population, these apparent benefits of statins have potentially important clinical implication. However, randomized controlled trials are clearly needed to establish the role of statins in the management of HFpEF.


Statins Heart failure with preserved ejection fraction Mortality Pleiotropic actions Left ventricular remodeling 


Compliance with ethical standards

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.First Propedeutic Department of Internal Medicine, Medical SchoolAristotle University of Thessaloniki, AHEPA HospitalThessalonikiGreece
  2. 2.Department of Cardiology, Medical SchoolAristotle University of Thessaloniki, AHEPA HospitalThessalonikiGreece

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