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Ultrasound findings in urogenital schistosomiasis: a pictorial essay

  • Diletta Cozzi
  • Elena Bertelli
  • Elena Savi
  • Silvia Verna
  • Lorenzo Zammarchi
  • Marta Tilli
  • Francesca Rinaldi
  • Silvia PradellaEmail author
  • Simone Agostini
  • Vittorio Miele
Pictorial Essay

Abstract

Urogenital schistosomiasis is a parasitic disease caused by S. haematobium which is endemic in tropical and sub-tropical areas but is increasingly diagnosed in temperate non-endemic countries due to migration and international travels. Early identification and treatment of the disease are fundamental to avoid associated severe sequelae such as bladder carcinoma, hydronephrosis leading to kidney failure and reproductive complications. Radiologic imaging, especially through ultrasound examination, has a fundamental role in the assessment of organ damage and follow-up after treatment. Imaging findings of urinary tract schistosomiasis are observed mainly in the ureters and bladder. The kidneys usually appear normal until a late stage of the disease.

Keywords

Ultrasound Infection Bladder Kidney Schistosoma 

Notes

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

This article does not contain any studies with human participants or animals performed by any of the authors.

References

  1. 1.
    Colley DG, Bustinduy AL, Secor WE, King CH (2014) Human schistosomiasis. Lancet 383:2253–2264CrossRefGoogle Scholar
  2. 2.
    Lingscheid T, Kurth F, Clerinx J, Marocco S, Trevino B, Schunk M et al (2017) Schistosomiasis in European travelers and migrants: analysis of 14 years TropNet Surveillance data. Am J Trop Med Hyg 97(2):567–574.  https://doi.org/10.4269/ajtmh.17-0034 CrossRefGoogle Scholar
  3. 3.
    Chitsulo L, Engels D, Montresor A, Savioli L (2000) The global status of schistosomiasis and its control. Acta Trop 77(1):41–51CrossRefGoogle Scholar
  4. 4.
    Buonfrate D, Gobbi F, Marchese V, Postiglione C, Badona-Monteiro G, Giorli G et al (2018) Extended screening for infectious diseases among newly-arrived asylum seekers from Africa and Asia, Verona province, Italy, April 2014 to June 2015. Eurosurveill.  https://doi.org/10.2807/1560-7917 Google Scholar
  5. 5.
    Scarlata F, Giordano S, Romani A, Marasa L, Lipani G, Infurnari L, Titone L (2005) Urinary schistosomiasis: remarks on a case. Infez Med 13(4):259–264Google Scholar
  6. 6.
    Barsoum RS (2003) Schistosomiasis and the kidney. Semin Nephrol 23:34–41CrossRefGoogle Scholar
  7. 7.
    Shebel HM, Elsayes KM, Abou El Atta HM, Elguindy YM, El-Diasty TA (2012) Genitourinary schistosomiasis: life cycle and radiologic-pathologic findings. Radiographics 32(4):1031–1046.  https://doi.org/10.1148/rg.324115162 CrossRefGoogle Scholar
  8. 8.
    Wu GY, Halim MH (2000) Schistosomiasis: progress and problems. World J Gastroenterol 6(1):12–19CrossRefGoogle Scholar
  9. 9.
    Corachan M (2002) Schistosomiasis and international travel. Clin Infect Dis 35(4):446–450CrossRefGoogle Scholar
  10. 10.
    Martínez S, Restrepo CS, Carrillo JA et al (2005) Thoracic manifestations of tropical parasitic infections: a pictorial review. Radiographics 25(1):135–155CrossRefGoogle Scholar
  11. 11.
    Poggensee G, Feldmeier H (2001) Female genital schistosomiasis: facts and hypotheses. Acta Trop 79(3):193–210CrossRefGoogle Scholar
  12. 12.
    Bichler KH, Savatovsky I, Naber KG, Bischop MC, Bjerklund-Johansen TE, Botto H et al (2006) EAU guidelines for the management of urogenital schistosomiasis. Eur Urol 49(6):998–1003CrossRefGoogle Scholar
  13. 13.
    Richter J, Botelho MC, Holtfreter MC, Akpata R, El Scheich T, Neumayr A et al (2016) Ultrasoundassessment of schistosomiasis. Z Gastroenterol 54(7):653–660CrossRefGoogle Scholar
  14. 14.
    Yong MK, Beckett CL, Leder K, Biggs BA, Torresi J, O’Brien DP (2010) Long-term follow-up of schistosomiasis serology post-treatment in Australian travelers and immigrants. J Trav Med 17(2):89–93CrossRefGoogle Scholar
  15. 15.
    Tilli M, Gobbi F, Rinaldi F, Testa J, Caligaris S, Magro P et al (2019) The diagnosis and treatment of urogenital schistosomiasis in Italy in a retrospective cohort of immigrants from South-Saharan Africa. Infection.  https://doi.org/10.1007/s15010-019-01270-0 Google Scholar
  16. 16.
    Akpata R, Neumayr A, Holtfreter MC, Krantz I, Singh DD, Mota R et al (2015) The WHO ultrasonography protocol for assessing morbidity due to Schistosoma haematobium. Acceptance and evolution over 14 years. Syst Rev Parasitol Res 114(4):1279–1289.  https://doi.org/10.1007/s00436-015-4389-z CrossRefGoogle Scholar
  17. 17.
    Richter J (2000) Ultrasound in Schistosomiasis. A practical guide to the standardized use of ultrasonography for the assessment of schistosomiasis-related morbidity. In: Second international workshop, October 22–26 1996, Niamey, Niger. Revised and updated. Geneva: World Health OrganizationGoogle Scholar
  18. 18.
    Barda B, Coulibaly JT, Hatz C, Keiser J (2017) Ultrasonographic evaluation of urinary tract morbidity in school-aged and preschool-aged children infected with Schistosoma haematobium and its evolution after praziquantel treatment: a randomized controlled trial. PLoS Negl Trop Dis 11(2):e0005400CrossRefGoogle Scholar
  19. 19.
    King CL, Malhotra I, Mungai P, Wamachi A, Kioko J, Muchiri E, Ouma JH (2001) Schistosoma haematobium-induced urinary tract morbidity correlated with increased tumor necrosis factor -alpha and diminished interleukin-10 production. J Infect Dis 184(9):1176–1182CrossRefGoogle Scholar
  20. 20.
    Wamachi AN, Mayadev JS, Mungai PL, Magak PL, Ouma JH, Magambo JK et al (2004) Increased ratio of tumor necrosis factor-alpha to interleukin-10 production is associated with Schistosoma haematobium-induced urinary-tract morbidity. J Infect Dis 190(11):2020–2030CrossRefGoogle Scholar
  21. 21.
    Khalaf I, Shokeir A, Shalaby M (2012) Urologic complications of genitourinary schistosomiasis. World J Urol 30(1):31–38.  https://doi.org/10.1007/s00345-011-0751-7 CrossRefGoogle Scholar
  22. 22.
    Yosry A (2006) Schistosomiasis and neoplasia. Contrib Microbiol 13:81–100CrossRefGoogle Scholar
  23. 23.
    Watanabe K, Muhoho ND, Mutua WR, Kiliku FM, Awazawa T, Moji K, Aoki Y (2011) Assessment of voiding function in inhabitants infected with Schistosoma haematobium. J Trop Pediatr 57(4):263–268.  https://doi.org/10.1093/tropej/fmq027 CrossRefGoogle Scholar
  24. 24.
    Duarte DB, Vanderlei LA, de Azevedo Bispo RK, Pinheiro ME, da Silva Junior GB, De Francesco Daher EF (2014) Acute kidney injury in Schistosomiasis: a retrospective cohort of 60 patients in Brazil. J Parasitol 101:244–247.  https://doi.org/10.1645/13-361.1 CrossRefGoogle Scholar
  25. 25.
    Ross AG, Bartley PB, Sleigh AC, Olds GR, Li Y, Williams GM et al (2002) Schistosomiasis. N Engl J Med 346(16):1212–1220CrossRefGoogle Scholar
  26. 26.
    Vilana R, Corachàn M, Gascòn J, Valls E, Bru C (1997) Schistosomiasis of the male genital tract: transrectal sonographic findings. J Urol 158(4):1491–1493CrossRefGoogle Scholar
  27. 27.
    Kayuni S, Lampiao F, Makaula P, Juziwelo L, Lacourse EJ, Reinhard-Rupp J et al (2018) A systematic review with epidemiological update of male genital schistosomiasis (MGS): a call for integrated case across the health system in sub-Saharan Africa. Parasite Epidemiol Control 23(4):e00077.  https://doi.org/10.1016/j.parepi.2018.e00077 Google Scholar
  28. 28.
    Murdoch DR (2003) Hematospermia due to schistosome infection in travelers. Clin Infect Dis 36(8):1086CrossRefGoogle Scholar
  29. 29.
    Soans B, Abel C (1999) Ultrasound appearance of schistosomiasis of the testis. Australas Radiol 43(3):385–387CrossRefGoogle Scholar
  30. 30.
    Goldsmith PC, Leslie TA, Sams V, Bryceson AD, Allason-Jones E, Dowd PM (1993) Lesions of the schistosomiasis mimicking warts on the vulva. BMJ 307:556–557CrossRefGoogle Scholar
  31. 31.
    Kimberly HH, Murray A, Mennicke M, Liteplo A, Lew J, Bohan JS et al (2010) Focused maternal ultrasound by midwives in rural Zambia. Ultrasound Med Biol 36:1267–1272CrossRefGoogle Scholar
  32. 32.
    Ben-Chetrit E, Lachish T, Mørch K, Atias D, Maguire C, Schwartz E (2014) Schistosomiasis in pregnant travelers: a case series. J Travel Med.  https://doi.org/10.1111/jtm.12165 Google Scholar

Copyright information

© Società Italiana di Ultrasonologia in Medicina e Biologia (SIUMB) 2019

Authors and Affiliations

  1. 1.Department of RadiologyCareggi University Hospital, AOU CareggiFlorenceItaly
  2. 2.Department of Experimental and Clinical MedicineUniversity of FlorenceFlorenceItaly
  3. 3.Infectious and Tropical Diseases UnitCareggi University HospitalFlorenceItaly

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