Alterations in Host Lipid Metabolism Produced During Visceral Leishmaniasis Infections
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Purpose of Review
Leishmania is an obligate intracellular parasite that depends on the host’s own lipid reservoirs to ensure its survival. The use of fats ranges from energy obtention to evasion of immune response, so this would alter the host’s lipid metabolism somehow. This article aims to review lipid metabolism of both parasite and host, and how the former affects the latter.
Leishmania uses the host’s cholesterol to ensure macrophage phagocytosis and evade immune response. Additionally, the host’s lipid bodies have key roles in disease progression and development of the parasite inside the cell. This induces changes in the patient’s serum lipid profile like hypertriglyceridemia and low HDL levels.
Changes in the lipid profile and metabolism in both parasite and host during development of the disease depend on the presence of lipid bodies. Further research is required to fully understand the relationship between the interactions between lipid metabolism of host and parasite, immune response, and the prognosis of the disease (Fig. 1).
KeywordsLipid metabolism in leishmaniasis Lipid bodies Visceral leishmaniasis Parasite metabolism
Compliance with Ethical Standards
Conflict of Interest
The authors declare that they have no conflict of interest.
Human and Animal Rights and Informed Consent
This article does not contain any studies with human or animal subjects performed by any of the authors.
Glossary of Key Terms
Gas chromatography-mass spectrometry
High density lipoprotein
Low density lipoprotein
Micro ribonucleic acids
Tumor necrosis factor
Very low density lipoprotein
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- 2.CDC. Leishmaniasis. 2017. Available from: https://www.cdc.gov/dpdx/leishmaniasis/index.html.
- 3.Costa-Barbossa F, Viera T, dos Santos M, dos Campos N, Ribeiro K, Cronemberg A, et al. Extracellular vesicles released by Leishmania (Leishmania) amazonensis promote disease progression and induce the production of different cytokines in macrophages and B-1 cells. Front Microbiol. 2018;9. https://doi.org/10.3989/fmicb.2018.03056.
- 4.McConville M, Naderer T. Metabolic pathways required for the intracellular survival of Leishmania. Annu Rev Microbiol. 2011;6:543–61. https://doi.org/10.1146/annurev-micro-090110-102913.CrossRefGoogle Scholar
- 5.Carroll K, Butel J, Morse S, Mietzner T. Parasitology: blood and tissue protozoan infections. In: Jawetz, Melnick & Adelberg’s Medical Microbiology. New York. 2016.Google Scholar
- 6.Organización Panamericana de la Salud. Leishmaniasis: Informe Epidemiológico de las Américas. Informe de Leishmaniasis N7: 2019.Google Scholar
- 12.•• Filippas-Ntekouan S, Liberopoulos E, Elisaf M. Lipid testing in infectious diseases: possible role in diagnosis and prognosis. Infection. 2017;45:575–88. https://doi.org/10.1007/s15010-017-1022-3. Filippas-Ntekouan. et al.provides important information about possible diagnostic indicators of leishmaniasis and their relationship with lipid metabolism of the infected host. CrossRefPubMedGoogle Scholar
- 14.•• Biagiotti M, Dominguez S, Yamout N, Zufferey R. Lipidomics and anti-trypanosomatid chemotherapy. Clin Transl Med. 2017;6(1). Biagiotti, Dominguez, Yamout and Zufferey wrote a review that establishes the utility of lipidomics to identify new lipids and determine changes in the lipid profile between Trypanosomatids.):27.CrossRefGoogle Scholar
- 16.• Yao C, Wilson ME. Dynamics of sterol synthesis during development of Leishmania spp. parasites to their virulent form. Parasit Vectors. 2016;9(1):1–12. https://doi.org/10.1186/s13071-016-1470-0Yao and Wilson describe the results of a GC-MS analysis to determine the changes in sterol synthesis during metacyclogenesis ofLeishmania infantumparasites. CrossRefGoogle Scholar
- 21.• Lima A, Teixeira L, da Silva K, Menezes C, Bozza P. Lipid droplet, a key player in host-parasite interactions. Front Immunol. 2018;9. https://doi.org/10.3389/fimmu.2018.01022Lima.et al.explains the dynamics of the lipid bodies and the mechanisms of formation during infectious disease such as leishmaniasis.
- 24.Paswan R, Bimal S, Kumari A, Sinha P, Rabidas V, Pandey K, et al. Reduced high density lipoprotein concentration modulates increased interleukin-10 and decreased interferon-gamma in visceral Leishmaniasis patients. 2016;4:2. https://doi.org/10.4172/2237-5146.1000233.
- 25.Nelson DL, Cox MM. Cholesterol, steroids and isoprenoids: biosynthesis, regulation and transport. In: Lehninger Principles of Biochemistry. New York: W.H. Freeman; 2017.Google Scholar