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Neurocognition and Suicide Risk in Adults

  • Kenneth J.D. AllenEmail author
  • Melanie L. Bozzay
  • Emma R. Edenbaum
Suicide (R Liu, Section Editor)
  • 9 Downloads
Part of the following topical collections:
  1. Topical Collection on Suicide

Abstract

Purpose of Review

Neurocognitive deficits (impaired mental abilities corresponding to brain dysfunction) are transdiagnostic features of psychiatric illness, which account for the vast majority of suicide deaths. Here, we provide a selective empirical overview of neurocognitive factors and associated pathophysiology implicated in adult suicide. The present report draws primarily from the neuropsychology literature to complement and update prior reviews and meta-analyses.

Recent Findings

Suicidality is linked to impairment across neurocognitive domains, particularly inhibition and decision-making components of executive functioning (EF).

Summary

Extant research has primarily examined “cool” EF in suicide, yet there is strong preliminary evidence for the importance of “hot” EF involved in affect regulation and value-based decision-making. Our review accordingly integrates what is known about neurocognition and suicidality under a conceptual framework informed by this literature and prior theory. We specifically propose that hot EF deficits represent a common pathway to suicide from various distal risk factors.

Keywords

Suicidality Suicidal ideation Neuropsychology Executive functioning Cognitive control Emotion 

Notes

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflicts of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. 1.
    Disease burden and mortality estimates. World Health Organization. https://www.who.int/healthinfo/global_burden_disease/estimates/en/. Published March 26, 2019. Accessed July 30, 2019.
  2. 2.
    Bachmann S. Epidemiology of suicide and the psychiatric perspective. Int J Environ Res Public Health. 2018;15(7):1–23.  https://doi.org/10.3390/ijerph15071425.CrossRefGoogle Scholar
  3. 3.
    Franklin JC, Ribeiro JD, Fox KR, et al. Risk factors for suicidal thoughts and behaviors: a meta-analysis of 50 years of research. Psychol Bull. 2017;143(2):187–232.  https://doi.org/10.1037/bul0000084.CrossRefPubMedGoogle Scholar
  4. 4.
    • Brick LA, Marraccini ME, Micalizzi L, Benca-Bachman CE, Knopik VS, Palmer RHC. Overlapping genetic effects between suicidal ideation and neurocognitive functioning. J Affect Disord. 2019;249(January):104–11.  https://doi.org/10.1016/j.jad.2019.02.003 Indicates shared heritability between the propensity to engage in suicidal thinking and hot neurocognition, specifically in emotion recognition ability. CrossRefPubMedGoogle Scholar
  5. 5.
    Erlangsen A, Appadurai V, Wang Y, et al. Genetics of suicide attempts in individuals with and without mental disorders: a population-based genome-wide association study. Mol Psychiatry. 2018.  https://doi.org/10.1038/s41380-018-0218-y.
  6. 6.
    Fu Q, Health AC, Bucholz KK, et al. A twin study of genetic and environmental influences on suicidality in men. Psychol Med. 2002;32(1):11–24.  https://doi.org/10.1017/S0033291701004846.CrossRefPubMedPubMedCentralGoogle Scholar
  7. 7.
    Ruderfer DM, Walsh CG, Aguirre MW, et al. Significant shared heritability underlies suicide attempt and clinically predicted probability of attempting suicide. Mol Psychiatry. 2019.  https://doi.org/10.1038/s41380-018-0326-8.
  8. 8.
    Nöthling J, Malan-Müller S, Abrahams N, Hemmings SMJ, Seedat S. Epigenetic alterations associated with childhood trauma and adult mental health outcomes: a systematic review. World J Biol Psychiatry. 2019;0(0):1–20.  https://doi.org/10.1080/15622975.2019.1583369.CrossRefGoogle Scholar
  9. 9.
    Bak J, Shim SH, Kwon YJ, et al. The association between suicide attempts and Toxoplasma gondii infection. Clin Psychopharmacol Neurosci. 2018;16(1):95–102.  https://doi.org/10.9758/cpn.2018.16.1.95.CrossRefPubMedPubMedCentralGoogle Scholar
  10. 10.
    Bozzay ML, Karver MS, Verona E. Linking insomnia and suicide ideation in college females: the role of socio-cognitive variables and depressive symptoms in suicide risk. J Affect Dis. 2016;199:106–13.  https://doi.org/10.1016/j.jad.2016.04.012.CrossRefPubMedGoogle Scholar
  11. 11.
    Lin HT, Lai CH, Perng HJ, et al. Insomnia as an independent predictor of suicide attempts: a nationwide population-based retrospective cohort study. BMC Psychiatry. 2018;18(1):1–11.  https://doi.org/10.1186/s12888-018-1702-2.CrossRefGoogle Scholar
  12. 12.
    Porras-Segovia A, Pérez-Rodríguez MM, López-Esteban P, et al. Contribution of sleep deprivation to suicidal behaviour: a systematic review. Sleep Med Rev. 2019;44:37–47.  https://doi.org/10.1016/j.smrv.2018.12.005.CrossRefPubMedGoogle Scholar
  13. 13.
    Tae H, Jeong BR, Chae JH. Sleep problems as a risk factor for suicide: are certain specific sleep domains associated with increased suicide risk? J Affect Disord. 2019;252(October 2018):182–9.  https://doi.org/10.1016/j.jad.2019.04.053.CrossRefPubMedGoogle Scholar
  14. 14.
    Poorolajal J, Haghtalab T, Farhadi M, Darvishi N. Substance use disorder and risk of suicidal ideation, suicide attempt, and suicide death: a meta-analysis. J Public Health. 2016;38:e282–91.  https://doi.org/10.1093/pubmed/fdv148.CrossRefGoogle Scholar
  15. 15.
    Madsen T, Erlangsen A, Orlovska S. Association between traumatic brain injury and risk of suicide. JAMA. 2018;320:580–8.  https://doi.org/10.1001/jama.2018.10211.CrossRefPubMedPubMedCentralGoogle Scholar
  16. 16.
    Wadhawan A, Stiller JW, Potocki E, et al. Traumatic brain injury and suicidal behavior: a review. J Alzheimers Dis. 2019;68(4):1339–70.  https://doi.org/10.3233/JAD181055.CrossRefPubMedGoogle Scholar
  17. 17.
    Stanley IH, Hom MA, Rogers ML, Hagan CR, Joiner TE. Understanding suicide among older adults: a review of psychological and sociological theories of suicide. Aging Ment Heal. 2016;20(2):113–22.  https://doi.org/10.1080/13607863.2015.1012045.CrossRefGoogle Scholar
  18. 18.
    Szanto K. Cognitive deficits: underappreciated contributors to suicide. Am J Geriatr Psychiatry. 2017;25(6):630–2.  https://doi.org/10.1016/j.jagp.2017.02.012.CrossRefPubMedPubMedCentralGoogle Scholar
  19. 19.
    •• Turecki G, Ernst C, Jollant F, Labonté B, Mechawar N. The neurodevelopmental origins of suicidal behavior. Trends Neurosci. 2012;35(1):14–23.  https://doi.org/10.1016/j.tins.2011.11.008 Reviews evidence for early environmental adversity contributing to a heightened stress response through epigenetic regulation of the hypothalamic-pituitary-adrenal axis, in turn increasing risk for suicide. The model proposed here extends this work by incorporating contemporary theories of transdiagnostic vulnerability to psychopathology . CrossRefPubMedGoogle Scholar
  20. 20.
    Harris EC, Barraclough B. Suicide as an outcome for mental disorders. Br J Psychiatry. 1997;170(3):205–28.  https://doi.org/10.1192/bjp.170.3.205.CrossRefPubMedGoogle Scholar
  21. 21.
    Goodwin FK, Jamison KR. Manic-depressive illness: bipolar disorders and recurrent depression. Oxford: Oxford University Press; 2007.Google Scholar
  22. 22.
    Bostwick JM, Pankratz VS. Reviews and overviews affective disorders and suicide risk: a reexamination. Am J Psychiatry. 2000;157(9):12.  https://doi.org/10.1176/appi.ajp.157.12.1925.CrossRefGoogle Scholar
  23. 23.
    Malone KM, Haas GL, Sweeney JA, Mann JJ. Major depression and the risk of attempted suicide. J Affect Disord. 1995;34(3):173–85.  https://doi.org/10.1016/0165-0327(95)00015-F.CrossRefPubMedGoogle Scholar
  24. 24.
    Benazzi F, Akiskal HS. Refining the evaluation of bipolar II: beyond the strict SCID-CV guidelines for hypomania. J Affect Disord. 2003;73(1–2):33–8.  https://doi.org/10.1016/S0165-0327(02)00327-0.CrossRefPubMedGoogle Scholar
  25. 25.
    Balázs J, Benazzi F, Rihmer Z, Rihmer A, Akiskal KK, Akiskal HS. The close link between suicide attempts and mixed (bipolar) depression: implications for suicide prevention. J Affect Disord. 2006;91(2–3):133–8.  https://doi.org/10.1016/j.jad.2005.12.049.CrossRefPubMedGoogle Scholar
  26. 26.
    Black DW, Blum N, Pfohl B, Hale N. Suicidal behavior in borderline personality disorder: prevalence, risk factors, prediction, and prevention. J Personal Disord. 2004;18(3):226–39.  https://doi.org/10.1521/pedi.18.3.226.35445.CrossRefGoogle Scholar
  27. 27.
    Allen KJD, Burke TA, Schatten HT, Armey MF, Hooley JM, Johnson SL. A multimethod empirical evaluation of the functional theory of p (Stage 1 Registered Report). J Res Pers 2019. https://osf.io/fpc5r/.
  28. 28.
    Carver CS, Johnson SL. Impulsive reactivity to emotion and vulnerability to psychopathology. AM Psychol. 2018;73(9):1067–78.  https://doi.org/10.1037/amp0000387.
  29. 29.
    • Carver CS, Johnson SL, Timpano KR. Toward a functional view of the p factor in psychopathology. Clin Psychol Sci. 2017;5(5):880–9.  https://doi.org/10.1177/2167702617710037 Proposes that common variance among psychiatric phenomena (i.e., the “p factor”) may reflect poor affective control, helping to explain related transdiagnostic risk factors (e.g., emotion dysregulation, rumination, urgency) that implicate hot executive functioning deficits. CrossRefPubMedPubMedCentralGoogle Scholar
  30. 30.
    Anestis MD, Joiner TE. Examining the role of emotion in suicidality: negative urgency as an amplifier of the relationship between components of the interpersonal-psychological theory of the suicidal behavior and lifetime number of suicide attempts. J Affect Disord. 2011;129(1–3):261–9.  https://doi.org/10.1016/j.jad.2010.08.006.CrossRefPubMedGoogle Scholar
  31. 31.
    Hamza CA, Willoughby T, Heffer T. Impulsivity and nonsuicidal self-injury: a review and meta-analysis. Clin Psychol Rev. 2015;38:13–24.  https://doi.org/10.1016/j.cpr.2015.02.010.CrossRefPubMedGoogle Scholar
  32. 32.
    Lynam DR, Miller JD, Miller DJ, Bornovalova MA, Lejuez CW. Testing the relations between impulsivity-related traits, suicidality, and nonsuicidal self-injury: a test of the incremental validity of the UPPS model. Personal Disord Theory Res Treat. 2011;2(2):151–60.  https://doi.org/10.1037/a0019978.CrossRefGoogle Scholar
  33. 33.
    Riley EN, Combs JL, Jordan CE, Smith GT. Negative urgency and lack of perseverance: identification of differential pathways of onset and maintenance risk in the longitudinal prediction of nonsuicidal self-injury. Behav Ther. 2015;46(4):439–48.  https://doi.org/10.1016/j.beth.2015.03.002.CrossRefPubMedPubMedCentralGoogle Scholar
  34. 34.
    Law KC, Tucker RP. Repetitive negative thinking and suicide: a burgeoning literature with a need for further exploration. Curr Opin Psychol. 2018;22:68–72.  https://doi.org/10.1016/j.copsyc.2017.08.027.CrossRefPubMedGoogle Scholar
  35. 35.
    Bloemen AJP, Oldehinkel AJ, Laceulle OM, Ormel J, Rommelse NNJ, Hartman CA. The association between executive functioning and psychopathology: general or specific? Psychol Med. 2018;48:1787–94.  https://doi.org/10.1017/S0033291717003269.CrossRefPubMedGoogle Scholar
  36. 36.
    Nigg JT. Annual research review: on the relations among self-regulation, self-control, executive functioning, effortful control, cognitive control, impulsivity, risk-taking, and inhibition for developmental psychopathology. J Child Psychol Psychiatry. 2017;58(4):361–83.  https://doi.org/10.1111/jcpp.12675.CrossRefPubMedGoogle Scholar
  37. 37.
    Nigg JT, Jester JM, Stavro GM, Ip KI, Puttler LI, Zucker RA. Specificity of executive functioning and processing speed problems in common psychopathology. Neuropsychol. 2017;31(4):448–66.  https://doi.org/10.1037/neu0000343.CrossRefGoogle Scholar
  38. 38.
    Snyder HR, Miyake A, Hankin BL. Advancing understanding of executive function impairments and psychopathology: bridging the gap between clinical and cognitive approaches. Front Psychol. 2015;6.  https://doi.org/10.3389/fpsyg.2015.00328.
  39. 39.
    Fineberg NA, Chamberlain SR, Goudriaan AE, et al. New developments in human neurocognition: clinical, genetic, and brain imaging correlates of impulsivity and compulsivity. CNS Spectr. 2014;19(1):69–89.  https://doi.org/10.1017/S1092852913000801.CrossRefPubMedPubMedCentralGoogle Scholar
  40. 40.
    Friedman NP, Miyake A. University and diversity of executive functions: individual differences as a window on cognitive structure. Cortex. 2017;86:186–204.  https://doi.org/10.1016/j.cortex.2016.04.023.CrossRefPubMedGoogle Scholar
  41. 41.
    Petrovic P, Castellanos FX. Top-down dysregulation—from ADHD to emotional instability. Front Behav Neurosci. 2016;10:1–25.  https://doi.org/10.3389/fnbeh.2016.00070.CrossRefGoogle Scholar
  42. 42.
    Schweizer S, Parker J, Leung JT, Griffin C, Blakemore SJ. Age-related differences in affective control and its association with mental health difficulties. Dev Psychopathol. 2019;25:1–13.  https://doi.org/10.1017/S0954579419000099.CrossRefGoogle Scholar
  43. 43.
    Zelazo PD, Qu L, Müller U. Hot and cool aspects of executive function: relations in early development. In: Schneider W, Schumann-Hengsteler R, Sodian B, eds. Young children’s cognitive development: interrelationships among executive functioning, working memory, verbal ability, and theory of mind. Mahwah, NJ: Erlbaum; 2005:71–93.Google Scholar
  44. 44.
    Bredemeier K, Miller IW. Executive function and suicidality: a systematic qualitative review. Clin Psychol Rev. 2015;40:170–83.  https://doi.org/10.1016/j.cpr.2015.06.005.CrossRefPubMedPubMedCentralGoogle Scholar
  45. 45.
    •• Cha CB, Wilson KM, Tezanos KM, DiVasto KA, Tolchin GK. Cognition and self-injurious thoughts and behaviors: a systematic review of longitudinal studies. Clin Psychol Rev. 2019;69(August 2018):97–111.  https://doi.org/10.1016/j.cpr.2018.07.002 Comprehensively reviews longitudinal studies of cognitive abilities and processes (including executive functions) in relation to nonsuicidal self-injury, suicidal ideation, and suicidal behaviors among different age groups. CrossRefPubMedGoogle Scholar
  46. 46.
    •• Saffer BY, Klonsky ED. Do neurocognitive abilities distinguish suicide attempters from suicide ideators? A systematic review of an emerging research area. Clin Psychol Sci Pract. 2018;25(1).  https://doi.org/10.1111/cpsp.12227 Synthesizes current knowledge of neurocognitive differences between patients with suicide attempt histories and those reporting only previous suicidal ideation (see Table 1).
  47. 47.
    • Naifeh, et al. Neurocognitive function and suicidal behavior in U.S. army soldiers. Suicide Life Threat Behav. 2017;47(5):589–602.  https://doi.org/10.1111/sltb.12307 A large military cohort study indicating that general neurocognitive impairment prospectively predicts suicidal ideation and behaviors. CrossRefPubMedGoogle Scholar
  48. 48.
    Richard-Devantoy S, Berlim MT, Jollant F. A meta-analysis of neuropsychological markers of vulnerability to suicidal behavior in mood disorders. Psychol Med. 2014;44(8):1663–73.  https://doi.org/10.1017/S0033291713002304.CrossRefPubMedGoogle Scholar
  49. 49.
    Richard-Devantoy S, Berlim MT, Jollant F. Suicidal behaviour and memory: a systematic review and meta-analysis. World J Biol Psychiatry. 2015;16(8):544–66.  https://doi.org/10.3109/15622975.2014.925584.CrossRefPubMedGoogle Scholar
  50. 50.
    Aldao A, Gee DG, De Los Reyes A, Seager I. Emotion regulation as a transdiagnostic factor in the development of internalizing and externalizing psychopathology: current and future directions. Dev Psychopathol. 2016;28(4):927–46.  https://doi.org/10.1017/S0954579416000638.CrossRefPubMedGoogle Scholar
  51. 51.
    Eisenberg IW, Bissett PG, Zeynep Enkavi A, et al. Uncovering the structure of self-regulation through data-driven ontology discovery. Nat Commun. 2019;10(1).  https://doi.org/10.1038/s41467-019-10301-1.
  52. 52.
    Halcomb M, Argyriou E, Cyders MA. Integrating preclinical and clinical models of negative urgency. Front Psychiatry. 2019;10:324):1–14.  https://doi.org/10.3389/fpsyt.2019.00324.CrossRefGoogle Scholar
  53. 53.
    Hamilton KR, Littlefield AK, Anastasio NC, et al. Rapid response impulsivity: definitions, measurement issues, and clinical implications. J Personal Disord. 2015;6(2):168–81.  https://doi.org/10.1037/per0000100.CrossRefGoogle Scholar
  54. 54.
    Hamilton KR, Mitchell MR, Wing VC, et al. Choice impulsivity: definitions, measurement issues, and clinical implications. J Personal Disord. 2015;6(2):182–98.  https://doi.org/10.1037/per0000099.CrossRefGoogle Scholar
  55. 55.
    Thompson RA. Emotion dysregulation: a theme in search of a definition. Dev Psychopathol. 2019;31(3):1–11.  https://doi.org/10.1017/S0954579419000282.CrossRefGoogle Scholar
  56. 56.
    Miller SN, Bozzay ML, Ben-Porath YS, Arbisi PA. Distinguishing levels of suicide risk in depressed male veterans: the role of internalizing and externalizing psychopathology as measured by the MMPI-2-RF. Assessment. 2019;26(1):85–98.  https://doi.org/10.1177/1073191117743787.CrossRefPubMedGoogle Scholar
  57. 57.
    De Raedt R, Koster EHW. Understanding vulnerability for depression from a cognitive neuroscience perspective: a reappraisal of attentional factors and a new conceptual framework. Cogn Affect Behav Neurosci. 2010;10(1):50–70.  https://doi.org/10.3758/CABN.10.1.50.CrossRefPubMedGoogle Scholar
  58. 58.
    Keilp JG, Sackeim HA, Brodsky BS, Oquendo MA, Malone KM, Mann JJ. Neuropsychological dysfunction in depressed suicide attempters. Am J Psychiatry. 2001;158:735–41.  https://doi.org/10.1017/S0033291714000786.CrossRefPubMedGoogle Scholar
  59. 59.
    Keilp JG, Gorlyn M, Oquendo MA, Burke AK, Mann JJ. Attention deficit in depressed suicide attempters. Psychiatry Res. 2008;159(1–2):7–17.  https://doi.org/10.1016/j.psychres.2007.08.020.CrossRefPubMedPubMedCentralGoogle Scholar
  60. 60.
    Keilp JG, Gorlyn M, Russell M, Oquendo MA, Burke AK, Harkavy-Friedman J, et al. Neuropsychological function and suicidal behavior: attention control, memory and executive dysfunction in suicide attempt. Psychol Med. 2013;43(3):539–51.  https://doi.org/10.1017/S0033291712001419.
  61. 61.
    Keilp JG, Beers SR, Burke AK, et al. Neuropsychological deficits in past suicide attempters with varying levels of depression severity. Psychol Med. 2014;44(14):2965–74.  https://doi.org/10.1017/S0033291714000786.CrossRefPubMedPubMedCentralGoogle Scholar
  62. 62.
    Stroop JR. Studies of interference in serial verbal reactions. J Exp Psychol Gen 1935;18:643-662. http://psychclassics.yorku.ca/Stroop/?c=012. Accessed June 4, 2019.
  63. 63.
    Thompson C, Ong ELC. The association between suicidal behavior, attentional control, and frontal asymmetry. Front Psychiatry. 2018;9:MAR):1–14.  https://doi.org/10.3389/fpsyt.2018.00079.CrossRefGoogle Scholar
  64. 64.
    Vadini F, Calella G, Pieri A, et al. Neurocognitive impairment and suicide risk among prison inmates. J Affect Disord. 2018;225(May 2017):273–7.  https://doi.org/10.1016/j.jad.2017.08.030.CrossRefPubMedGoogle Scholar
  65. 65.
    Hung Y, Gaillard SL, Yarmak P, Arsalidou M. Dissociations of cognitive inhibition, response inhibition, and emotional interference: voxelwise ALE meta-analyses of fMRI studies. Hum Brain Mapp. 2018;39(10):4065–85.  https://doi.org/10.1002/hbm.24232.CrossRefPubMedGoogle Scholar
  66. 66.
    Robins TW, et al. Neurocognitive endophenotypes of impulsivity and compulsivity: towards dimensional psychiatry. Trends Cogn Sci. 2012;16(1):81–91.  https://doi.org/10.1016/j.tics.2011.11.009.CrossRefGoogle Scholar
  67. 67.
    Chi-Shin W, et al. Multidimensional assessments of impulsivity in subjects with history of suicidal attempts. Compr Psychiatry. 2009;50(4):315–21.  https://doi.org/10.1016/j.comppsych.2008.09.006.CrossRefGoogle Scholar
  68. 68.
    Dougherty DM, Mathias CW, Marsh DM, Papageorgiou TD, Swann AC, Moeller FG. Laboratory measured behavioral impulsivity relates to suicide attempt history. Suicide Life-Threatening Behav. 2004;34(4):374–85.  https://doi.org/10.1521/suli.34.4.374.53738.CrossRefGoogle Scholar
  69. 69.
    Swann AC, Dougherty DM, Pazzaglia PJ, Pham M, Steinberg JL, Moeller FG. Increased impulsivity associated with severity of suicide attempt history in patients with bipolar disorder. Am J Psychiatry. 2005;162(9):1680–7.  https://doi.org/10.1176/appi.ajp.162.9.1680.CrossRefPubMedGoogle Scholar
  70. 70.
    Westheide J, Quednow BB, Kuhn KU, et al. Executive performance of depressed suicide attempters: the role of suicidal ideation. Eur Arch Psychiatry Clin Neurosci. 2008;258(7):414–21.  https://doi.org/10.1007/s00406-008-0811-1.CrossRefPubMedGoogle Scholar
  71. 71.
    Millner AJ, Lee MD, Hoyt K, Buckholtz JW, Auerbach RP, Nock MK. Are suicide attempters more impulsive than suicide ideators? Gen Hosp Psychiatry. 2018;(August):0–1.  https://doi.org/10.1016/j.genhosppsych.2018.08.002.
  72. 72.
    Ho MC, Hsu YC, Lu ML, Gossop M, Chen VCH. ‘Cool’ and ‘hot’ executive functions in suicide attempters with major depressive disorder. J Affect Disord. 2018;235:332–40.  https://doi.org/10.1016/j.jad.2018.04.057.CrossRefPubMedGoogle Scholar
  73. 73.
    Miranda R, Gallagher M, Bauchner B, Vaysman R, Marroquin B. Cognitive inflexibility as a prospective predictor of suicidal ideation among young adults with a suicide attempt history. Depress Anxiety. 2012;29(3):180–6.  https://doi.org/10.1002/da.20915.CrossRefPubMedGoogle Scholar
  74. 74.
    Miranda R, Valderrama J, Tsypes A, Gadol E, Gallagher M. Cognitive inflexibility and suicidal ideation: mediating role of brooding and hopelessness. Psychiatry Res. 2013;210(1):174–81.  https://doi.org/10.1016/j.psychres.2013.02.033.CrossRefPubMedPubMedCentralGoogle Scholar
  75. 75.
    Crandall AA, Allsop Y, Hanson CL. The longitudinal association between cognitive control capacities, suicidality, and depression during late adolescence and young adulthood. J Adolesc. 2018;65(October 2017):167–76.  https://doi.org/10.1016/j.adolescence.2018.03.009.CrossRefPubMedGoogle Scholar
  76. 76.
    Williams JM, Broadbent K. Autobiographical memory in suicide attempters. J Abnorm Psychol. 1986;95(2):144–9.  https://doi.org/10.1037/0021-843X.95.2.144.CrossRefPubMedGoogle Scholar
  77. 77.
    Canal-Rivero M, López-Moríñigo JD, Setién-Suero E, et al. (2018). Predicting suicidal behaviour after first episode of non-affective psychosis: the role of neurocognitive functioning. J Eur Psychiatry 2018;53:52–57. doi:  https://doi.org/10.1016/j.eurpsy.2018.06.001.
  78. 78.
    Jollant F, Lawrence NL, Olié E, Guillaume S, Courtet P. The suicidal mind and brain: a review of neuropsychological and neuroimaging studies. World J Biol Psychiatry. 2011;12(5):319–39.  https://doi.org/10.3109/15622975.2011.556200.CrossRefPubMedGoogle Scholar
  79. 79.
    Marx I, Krause J, Berger C, Häßler F. Dissociable patterns in the control of emotional interference in adults with attention-deficit/hyperactivity disorder (ADHD) and in adults with alcohol dependence. PLoS One. 2014;9(9).  https://doi.org/10.1371/journal.pone.0107750.
  80. 80.
    Nolen-Hoeksema S, Wisco BE, Lyubormirsky S. Rethinking rumination. Perspect Psychol Sci. 2008;3(5):400–24.  https://doi.org/10.1111/j.1745-6924.2008.00088.CrossRefPubMedGoogle Scholar
  81. 81.
    King KM, Feil MC, Halvorson MA. Negative urgency is correlated with the use of reflexive and disengagement emotion regulation strategies. Clin Psychol Sci. 2018;6(6):822–34.  https://doi.org/10.1177/2167702618785619.CrossRefGoogle Scholar
  82. 82.
    Gaweda Ł, Pionke R, Krezołek M, Frydecka D, Nelson B, Cechnicki A. The interplay between childhood trauma, cognitive biases, psychotic-like experiences and depression and their additive impact on predicting lifetime suicidal behavior in young adults. Psychol Med. 2018:1–9.  https://doi.org/10.1017/S00332917180040.
  83. 83.
    O’Connor RC, Nock MK. The psychology of suicidal behaviour. Lancet Psychiatry. 2014;1(1):73–85.  https://doi.org/10.1016/S2215-0366(14)70222-6.CrossRefPubMedGoogle Scholar
  84. 84.
    Wenzel AE, Beck AT. A cognitive model of suicidal behavior: theory and treatment. App Prevent Psychol. 2008;12(4):189–201.  https://doi.org/10.1016/j.appsy.2008.05.001.CrossRefGoogle Scholar
  85. 85.
    Jollant F, Lawrence NS, Giampietro V, et al. Orbitofrontal cortex response to angry faces in men with histories of suicide attempts. Am J Psychiatry. 2008;165(6):740–8.  https://doi.org/10.1176/appi.ajp.2008.07081239.CrossRefPubMedGoogle Scholar
  86. 86.
    Chung Y, Jeglic EL. Detecting suicide risk among college students: a test of the predictive validity of the modified emotional Stroop Task. Suicide Life Threat Behav. 2017;47(4):398–409.  https://doi.org/10.1111/sltb.12287.CrossRefPubMedGoogle Scholar
  87. 87.
    Becker ES, Strohbach D, Rinck M. A specific attentional bias in suicide attempters. J Nerv Ment Dis. 1999;187(12):730–5.  https://doi.org/10.1097/00005053-199912000-00004.CrossRefPubMedGoogle Scholar
  88. 88.
    Cha CB, Najmi S, Park JM, Finn CT, Nock MK. Attentional bias toward suicide-related stimuli predicts suicidal behavior. J Abnorm Psychol. 2010;119(3):616–22.  https://doi.org/10.1037/a0019710.CrossRefPubMedPubMedCentralGoogle Scholar
  89. 89.
    Richard-Devantoy S, Ding Y, Lepage M, Turecki G, Jollant F. Cognitive inhibition in depression and suicidal behavior: a neuroimaging study. Psychol Med. 2016;46(5):933–44.  https://doi.org/10.1017/S0033291715002421.CrossRefPubMedGoogle Scholar
  90. 90.
    Wilson KM, Millner AJ, Auerbach RP, Glenn CR, Kearns JC, Kirtley OJ, et al. Investigating the psychometric properties of the Suicide Stroop Task. Psychol Assess. 2019; e-published ahead of print.  https://doi.org/10.1037/pas0000723.
  91. 91.
    Fortgang RG, Hultman CM, Van Erp TGM, Cannon TD. Multidimensional assessment of impulsivity in schizophrenia, bipolar disorder, and major depressive disorder: testing for shared endophenotypes. Psychol Med. 2016;46(7):1497–507.  https://doi.org/10.1017/S0033291716000131.CrossRefPubMedGoogle Scholar
  92. 92.
    Moeller FG, Barratt ES, Dougherty DM, Schmitz JM, Swann AC. Reviews and overviews psychiatric aspects of impulsivity. Psychiatry Interpers Biol Process. 2001;158(November):1783–93.  https://doi.org/10.1111/j.1467-789X.2011.00899.x.CrossRefGoogle Scholar
  93. 93.
    Courtet P, Gottesman II, Jollant F, Gould TD. The neuroscience of suicidal behaviors: what can we expect from endophenotype strategies? Transl Psychiatry. 2011;1(5):e7–7.  https://doi.org/10.1038/tp.2011.6.
  94. 94.
    Mann JJ, Arango VA, Avenevoli S, et al. Candidate endophenotypes for genetic studies of suicidal behavior. Biol Psychiatry. 2009;65(7):556–63.  https://doi.org/10.1016/j.biopsych.2008.11.021.CrossRefPubMedPubMedCentralGoogle Scholar
  95. 95.
    • Allen KJD, Hooley JM. Negative emotional action termination (NEAT): support for a cognitive mechanism underlying negative urgency in nonsuicidal self-injury. Behav Ther. 2019;50(5):924–37.  https://doi.org/10.1016/j.beth.2019.02.001 Empirical study suggesting that late-stage negative emotional response inhibition may be a neurocognitive mechanism for urgency, a transdiagnostic construct associated with emotion dysregulation and psychopathology, including self-injurious thoughts and behaviors. Deficits in this process implicate hot executive dysfunction. CrossRefPubMedGoogle Scholar
  96. 96.
    Gay P, Rochat L, Billieux J, d’Acremont M, Van der Linden M. Heterogeneous inhibition processes involved in different facets of self-reported impulsivity: evidence from a community sample. Acta Psychol. 2008;129(3):332–9.  https://doi.org/10.1016/j.actpsy.2008.08.010.CrossRefGoogle Scholar
  97. 97.
    Rudd MD. Fluid vulnerability theory: a cognitive approach to understanding the process of acute and chronic suicide risk. In: Ellis TE, editor. Cognition and suicide: theory, research, and therapy. Washington, DC, US: American Psychological Association; 2006.Google Scholar
  98. 98.
    Oquendo MA, Galfalvy H, Russo S, et al. Prospective study of clinical predictors of suicidal acts after a major depressive episode in patients with major depressive disorder or bipolar disorder. Am J Psychiatry. 2004;161(8):1433–41.  https://doi.org/10.1176/appi.ajp.161.8.1433.CrossRefPubMedGoogle Scholar
  99. 99.
    Hinvest NS, Elliott R, McKie S, Anderson IM. Neural correlates of choice behavior related to impulsivity and venturesomeness. Neuropsychologia. 2011;49(9):2311–20.  https://doi.org/10.1016/j.neuropsychologia.2011.02.023.CrossRefPubMedGoogle Scholar
  100. 100.
    Murphy FC, Nimmo-Smith I, Lawrence AD. Functional neuroanatomy of emotions: a meta-analysis. Cogn Affect Behav Neurosci. 2003;3(3):207–33.  https://doi.org/10.3758/CABN.3.3.207.CrossRefPubMedGoogle Scholar
  101. 101.
    Phan KL, Wager T, Taylor SF, Liberzon I. Functional neuroanatomy of emotion: a meta-analysis of emotion activation studies in PET and fMRI. Neuroimage. 2002;16(2):331–48.  https://doi.org/10.1006/nimg.2002.1087.CrossRefPubMedGoogle Scholar
  102. 102.
    Phan KL, Wager TD, Taylor SF, Liberzon I. Functional neuroimaging studies of human emotions. CNS Spectr. 2004;9(4):258–66.  https://doi.org/10.1017/S1092852900009196.CrossRefPubMedGoogle Scholar
  103. 103.
    Harfmann EJ, Rhyner KT, Ingram RE. Cognitive inhibition and attentional biases in the affective go/no-go performance of depressed, suicidal populations. J Affect Disord. 2019;256:228–33.  https://doi.org/10.1016/j.jad.2019.05.022.CrossRefPubMedGoogle Scholar
  104. 104.
    Allen KJD, Hooley JM. Inhibitory control in people who self-injure: evidence for impairment and enhancement. Psychiatry Res. 2015;225(3):631–7.  https://doi.org/10.1016/j.psychres.2014.11.033.CrossRefPubMedGoogle Scholar
  105. 105.
    Allen KJD, Hooley JM. Negative mood and interference control in nonsuicidal self-injury. Compr Psychiatry. 2017;73:35–42.  https://doi.org/10.1016/j.comppsych.2016.10.011.CrossRefPubMedGoogle Scholar
  106. 106.
    Allen KJD, Schatten HT, Nugent NR, Armey MF. Inhibitory control over emotion mediates the association between childhood trauma and suicidal behavior: a neurobehavioral “scar” of early abuse and neglect. Paper presented at the 53rd Annual Convention of the Association for Behavioral and Cognitive Therapies; November, 2019; Atlanta, GA.Google Scholar
  107. 107.
    Hoehne A, Richard-Devantoy S, Ding T, Turecki G, Jollant F. First-degree relatives of suicide completers may have impaired decision-making but functional cognitive control. J Psychiatr Res. 2015;68:192–7.  https://doi.org/10.1016/j.jpsychires.2015.07.004.CrossRefPubMedGoogle Scholar
  108. 108.
    Bechara A, Damasio AR, Damasio H, Anderson SW. Insensitivity to future consequences following damage to human prefrontal cortex. Cognition. 1994;50(1–3):7–15.  https://doi.org/10.1016/0010-0277(94)90018-3.CrossRefPubMedGoogle Scholar
  109. 109.
    Deisenhammer EA, Schmid SK, Kemmler G, Moser B, Delazer M. Decision making under risk and under ambiguity in depressed suicide attempters, depressed non-attempters and healthy controls. J Affect Disord. 2018;226:261–6.  https://doi.org/10.1016/j.jad.2017.10.012.CrossRefPubMedGoogle Scholar
  110. 110.
    Hegedűs KM, Szkaliczki A, Gál BI, Andó B, Janka Z, Álmos PZ. Decision-making performance of depressed patients within 72 h following a suicide attempt. J Affect Disord. 2018;235:583–8.  https://doi.org/10.1016/j.jad.2018.04.082.CrossRefPubMedGoogle Scholar
  111. 111.
    •• Millner AJ, Den Ouden HEM, Gershman SJ, et al. Suicidal thoughts and behaviors are associated with an increased decision-making bias for active responses to escape aversive states. J Abnorm Psychol. 2019;128(2):106–18.  https://doi.org/10.1037/abn0000395 This well-designed empirical study illustrates the promise of computational techniques to advance our understanding of specific mechanisms within a neurocognitive ability (or set of abilities) that may distinguish individuals at heightened suicide risk. CrossRefPubMedGoogle Scholar
  112. 112.
    Beard C, Rifkin LS, Björgvinsson T. Characteristics of interpretation bias and relationship with suicidality in a psychiatric hospital sample. J Affect Disord. 2017;207:321–6.  https://doi.org/10.1016/j.jad.2016.09.021.CrossRefPubMedGoogle Scholar
  113. 113.
    Joormann J, Tran TB. Rumination and intentional forgetting of emotional material. Cogn Emot. 2009;23(6):1233–46.  https://doi.org/10.1080/02699930802416735.CrossRefGoogle Scholar
  114. 114.
    Power MJ, Dalgleish T, Claudio V, Tata P, Kentish J. The directed forgetting task: application to emotionally valent material. J Affect Disord. 2000;57(1–3):147–57.  https://doi.org/10.1016/S0165-0327(99)00084-1.CrossRefPubMedGoogle Scholar
  115. 115.
    Korfine L, Hooley JM. Directed forgetting of emotional stimuli in borderline personality disorder. J Abnorm Psychol. 2000;109(2):214–21.  https://doi.org/10.1037/0021-843X.109.2.214.CrossRefPubMedGoogle Scholar
  116. 116.
    Best SG, Allen KJD, Hooley JM. Nonsuicidal self-injury and directed forgetting 2019. Manuscript under review.Google Scholar
  117. 117.
    Denny KG, Siemer M. Trait aggression is related to anger-modulated deficits in response inhibition. J Res Pers. 2012;46(4):450–4.  https://doi.org/10.1016/j.jrp.2012.04.001.CrossRefGoogle Scholar
  118. 118.
    McDonald J, Bozzay M, Bresin K, Verona E. Common and unique factors of externalizing psychopathology in relation to inhibitory control and error processing. Internat J Psychopathol 2019. Manuscript under review.Google Scholar
  119. 119.
    van Heeringen K. Stress-diathesis model of suicidal behavior. In: The neurobiological basis of suicide. Edited by Dwivedi Y. Boca Raton (FL); 2012.Google Scholar
  120. 120.
    van Heeringen K, Mann JJ. The neurobiology of suicide. Lancet Psychiatry. 2014;1(1):63–72.  https://doi.org/10.1016/S2215-0366(14)70220-2.CrossRefPubMedGoogle Scholar
  121. 121.
    •• van Heeringen K, Bijttebier S, Desmyter S, Vervaet M, Baeken C. Is there a neuroanatomical basis of the vulnerability to suicidal behavior? A coordinate-based meta-analysis of structural and functional MRI studies. Front Hum Neurosci. 2014;8(October):1–8.  https://doi.org/10.3389/fnhum.2014.00824 This meta-analysis of MRI studies links suicidal behavior with structural deficits and functional overactivity in brain regions that correspond to reduced motivational control over responses to negative information . CrossRefGoogle Scholar
  122. 122.
    Raust A, Slama F, Mathieu F, et al. Prefrontal cortex dysfunction in patients with suicidal behavior. Psychol Med. 2007;37(3):411–9.  https://doi.org/10.1017/S0033291706009111.CrossRefPubMedGoogle Scholar
  123. 123.
    Zhang H, Chen Z, Jia Z, Gong Q. Dysfunction of neural circuitry in depressive patients with suicidal behaviors: a review of structural and functional neuroimaging studies. Progress Neuropsychopharm Biol Psychiatry. 2014;53:61–6.CrossRefGoogle Scholar
  124. 124.
    Oquendo MA, Placidi GP, Malone KM, et al. Positron emission tomography of regional brain metabolic responses to a serotonergic challenge and lethality of suicide attempts in major depression. Arch Gen Psychiatry. 2003;60(1):14–22.  https://doi.org/10.1001/archpsyc.60.1.14.CrossRefPubMedGoogle Scholar
  125. 125.
    Monkul ES, Hatch JP, Nicoletti MA, et al. Fronto-limbic brain structures in suicidal and non-suicidal female patients with major depressive disorder. Mol Psychiatry. 2007;12(4):360–6.  https://doi.org/10.1038/sj.mp.4001919.CrossRefPubMedGoogle Scholar
  126. 126.
    Comte M, Schön D, Coull JT, et al. Dissociating bottom-up and top-down mechanisms in the cortico-limbic system during emotion processing. Cereb Cortex. 2016;26(1):144–55.  https://doi.org/10.1093/cercor/bhu185.CrossRefPubMedGoogle Scholar
  127. 127.
    Black C, Miller BJ. Meta-analysis of cytokines and chemokines in suicidality: distinguishing suicidal versus nonsuicidal patients. Biol Psychiatry. 2015;78(1):28–37.  https://doi.org/10.1016/j.biopsych.2014.10.014.CrossRefPubMedGoogle Scholar
  128. 128.
    Ganança L, Oquendo MA, Tyrka AR, Cisneros-Trujillo S, Mann JJ, Sublette ME. The role of cytokines in the pathophysiology of suicidal behavior. Psychoneuroendocrinology. 2016;63:296–310.  https://doi.org/10.1016/j.psyneuen.2015.10.008.CrossRefPubMedGoogle Scholar
  129. 129.
    Richard-Devantoy S, Olié E, Guillaume S, Bechara A, Courtet P, Jollant F. Distinct alterations in value-based decision-making and cognitive control in suicide attempters: toward a dual neurocognitive model. J Affect Disord. 2013;151(3):1120–4.  https://doi.org/10.1016/j.jad.2013.06.052.CrossRefPubMedGoogle Scholar
  130. 130.
    Busch KA, Fawcett J, Jacobs DG. Clinical correlates of inpatient suicide. J Clin Psychiatry. 2003;64(1):14–9.  https://doi.org/10.4088/JCP.v64n0105.CrossRefPubMedGoogle Scholar
  131. 131.
    Schatten HT, Allen KJD, Armey MF. Assessment of emotion dysregulation using ecological momentary assessment. In: In: The Oxford handbook of emotion dysregulation. Edited by Beauchaine TP and Crowell SE. New York (NY); 2019. doi: https://doi.org/10.1093/oxfordhb/9780190689285.013.29.

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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Department of PsychologyOberlin CollegeOberlinUSA
  2. 2.Department of Psychiatry & Human BehaviorAlpert Medical School of Brown UniversityProvidenceUSA
  3. 3.Psychosocial Research ProgramButler HospitalProvidenceUSA
  4. 4.Center for Neurorestoration and NeurotechnologyProvidence VA Medical CenterProvidenceUSA

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