Metrics of Aging in Transplantation
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Purpose of Review
To describe potential metrics of aging beyond chronological age and their associations with outcomes after solid organ transplantation.
Investigation in this field has focused primarily on two areas: biomarkers related to replicative cell senescence and frailty and constructs related to frailty (e.g., sarcopenia, physical performance). Indicators of replicative senescence and frailty are more prevalent among transplant candidates than in the general elderly population, and both have been shown in recent studies to be associated with adverse outcomes following transplantation.
Despite substantial evidence supporting the prognostic utility of these indicators, and of physical frailty in particular, no consensus has emerged about the best metric within individual organ specialty groups or across specialties. Research is ongoing to identify the most useful measure or set of measures.
KeywordsTransplant Elderly Aging Frailty
Compliance with Ethical Standards
Conflict of Interest
Kirsten Johansen receives personal fees from Glaxo-SmithKline, outside the submitted work.
Human and Animal Rights and Informed Consent
This article does not contain any studies with human or animal subjects performed by any of the authors.
Papers of particular interest, published recently, have been highlighted as: •• Of major importance
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