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Metrics of Aging in Transplantation

  • Kirsten L. JohansenEmail author
Frailty and Gerontology (M McAdams-Demarco, Section Editor)​
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Part of the following topical collections:
  1. Topical Collection on Frailty and Gerontology

Abstract

Purpose of Review

To describe potential metrics of aging beyond chronological age and their associations with outcomes after solid organ transplantation.

Recent Findings

Investigation in this field has focused primarily on two areas: biomarkers related to replicative cell senescence and frailty and constructs related to frailty (e.g., sarcopenia, physical performance). Indicators of replicative senescence and frailty are more prevalent among transplant candidates than in the general elderly population, and both have been shown in recent studies to be associated with adverse outcomes following transplantation.

Summary

Despite substantial evidence supporting the prognostic utility of these indicators, and of physical frailty in particular, no consensus has emerged about the best metric within individual organ specialty groups or across specialties. Research is ongoing to identify the most useful measure or set of measures.

Keywords

Transplant Elderly Aging Frailty 

Notes

Compliance with Ethical Standards

Conflict of Interest

Kirsten Johansen receives personal fees from Glaxo-SmithKline, outside the submitted work.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

References

Papers of particular interest, published recently, have been highlighted as: •• Of major importance

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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Hennepin HealthcareMinneapolisUSA

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