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Artificial Lungs: Current Status and Future Directions

  • Ryan A. Orizondo
  • Arturo J. Cardounel
  • Robert Kormos
  • Pablo G. SanchezEmail author
Thoracic Transplantation (J Kobashigawa and J Patel, Section Editors)
  • 19 Downloads
Part of the following topical collections:
  1. Topical Collection on Thoracic Transplantation

Abstract

Purpose of Review

Although lung transplantation can be used to treat lung failure, limited donor organ availability creates a pressing need for improved artificial lung technology. This review discusses recent developments and future research pathways for respiratory assist devices and regenerative therapies intended to treat advanced lung disease.

Recent Findings

Hollow fiber membrane gas exchangers can be used to bridge lung failure patients to transplantation. Engineering improvements to such devices are on the verge of enabling longer term wearable systems that simplify and improve support. Progress with microchannel-based devices provides hope of smaller, more biomimetic devices that may even enable implantation; however, further development and testing are needed. Advances in cell-based technologies and tissue engineering have enabled early proof of concept of bioartificial lungs with properties similar to the native organ.

Summary

Recent progress with artificial lungs has enabled better treatment as a bridge therapy. Continued advances in both engineering and biology will be necessary to achieve a truly implantable artificial lung capable of destination therapy.

Keywords

Artificial lungs Oxygenator Lung disease Lung transplantation Extracorporeal membrane oxygenation 

Notes

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

All reported studies/experiments with human or animal subjects performed by the authors have been previously published and complied with all applicable ethical standards (including the Helsinki declaration and its amendments, institutional/national research committee standards, and international/national/institutional guidelines).

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Ryan A. Orizondo
    • 1
    • 2
    • 3
  • Arturo J. Cardounel
    • 4
  • Robert Kormos
    • 1
    • 3
    • 4
  • Pablo G. Sanchez
    • 4
    Email author
  1. 1.McGowan Institute for Regenerative MedicineUniversity of PittsburghPittsburghUSA
  2. 2.Department of MedicineUniversity of PittsburghPittsburghUSA
  3. 3.Department of BioengineeringUniversity of Pittsburgh Medical CenterPittsburghUSA
  4. 4.Department of Cardiothoracic Surgery, Division of Thoracic SurgeryUniversity of Pittsburgh Medical CenterPittsburghUSA

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