Evaluation of thrombogenic potential by partial differential equations in the blood flow dynamics with central venous catheter
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This paper presents for the first time a numerical prediction of the thrombogenic potential by means of partial differential equation in computational fluid dynamics for cardiovascular devices. To quantify the thrombogenic potential was developed the Platelet Lysis Index equation in an Eulerian model. Six different catheter tip models with the results obtained from the literature, however, with Lagrangian approach were compared. Three-dimensional computational fluid dynamics was done with a realistic central venous catheter model. The partial differential equation covers the entire computational domain, allowing the visualization of the regions with the highest platelet activation. In the realistic catheter, the first arterial proximal hole was the region with the highest Platelet Lysis Index and shear rate. Despite all limitations and considerations, the use of the Eulerian model allows a quick numerical comparison of the thrombogenic potential of cardiovascular device, being a useful tool in its design.
KeywordsComputational fluid dynamics Central venous catheters Platelet activation
Jonathas Haniel and Rudolf Huebner analyzed the data and designed, drafted, critically revised and approved the article. Thabata Coaglio Lucas provided the concept and interpreted, drafted, critically revised and approved the article.
This work was supported by the National Council for Scientific and Technological Development (CNPq) under Grant [401217/2016-7].
Compliance with ethical standards
Conflict of interest
The authors have no professional or financial conflicts of interest to disclose.
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