Acquisition of Streptococcus mutans and dental caries experience in pediatric sickle cell anaemia patients under various prophylactic therapies

  • S. Hanumanta
  • R. M. ShettyEmail author
  • O. Khandwal
  • S. Rath
  • S. Y. Shetty
  • R. K. Diwan
Original Scientific Article



To determine the acquisition of Streptococcus mutans and dental caries experience in children with sickle cell anaemia (SCA) under various prophylactic therapies.


This study involved a total of 200 children who were divided into five groups comprising of 40 children each. Group SP included children who received prophylactic penicillin, Group SV who received pneumococcal vaccination, Group SPV who received both prophylactic penicillin and pneumococcal vaccination, Group SW who did not receive any prophylactic therapy and Group CC who were controls. Stimulated saliva samples from volunteers were collected and cultured in Mitis Salivarius Bacitracin (MSB) agar for estimation of Streptococcus mutans. Decayed, Missing, Filled (DMFT) index/decayed, exfoliated, and filled tooth (deft) index was used for assessment of dental caries.


Group SP, Group SV, and Group SPV showed statistically significant difference in Streptococcus mutans count and dental caries experience in children when compared to Group SW and Group CC (p < 0.05) with the maximum reduction in Group SPV. No significant differences were observed in Group SW and Group CC.


Reduction in the Streptococcus mutans acquisition and dental caries experience was seen in children with SCA who received prophylactic therapy with the least acquisition in combination therapy (Group SPV).


Antibiotic prophylaxis Dental caries Pneumococcal vaccination Sickle cell anaemia Streptococcus mutans 


Compliance with ethical standards

Conflict of interest

The authors declare that they have no competing interest.


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Copyright information

© European Academy of Paediatric Dentistry 2019

Authors and Affiliations

  1. 1.Department of Paedodontics and Preventive DentistryGovernment Dental CollegeRaipurIndia
  2. 2.Department of Preventive and Paediatric and Dentistry, College of DentistryGulf Medical UniversityAjmanUnited Arab Emirates
  3. 3.Department of PaediatricsPt. J. N. M. Medical CollegeRaipurIndia
  4. 4.Department of Paedodontics and Preventive DentistryHi Tech Dental College and HospitalBhubaneshwarIndia
  5. 5.Department of PeriodonticsMaitri Dental CollegeDurgIndia
  6. 6.Department of Oral Medicine and RadiologyMaitri Dental CollegeDurgIndia

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