European Archives of Paediatric Dentistry

, Volume 17, Issue 4, pp 245–250 | Cite as

Peripartum events and molar-incisor hypomineralisation (MIH) amongst young patients in southwest France

  • E. GarotEmail author
  • D. Manton
  • P. Rouas
Original Scientific Article



This was to investigate the association of peripartum events with the occurrence of MIH.


This study, carried out between 2010 and 2011, was based on objective information noted in child health booklets on putative risk factors for MIH during the Peripartum period, aged between 6 to 28 years. The target population consisted of patients with MIH and a control group. Among the 849 patients examined by two calibrated paediatric dentists, 75 patients with MIH were recorded. These patients attended for consultation either at the teaching dental hospital of Bordeaux (France) or at a private dental practice (Bordeaux, France). Pearson’s Chi-squared test was used and Odds ratios (OR) with 95 % test-based confidence intervals (CI) were calculated.


Correlations were observed between hypoxia during delivery and occurrence of MIH (OR = 6.1; CI = 1.7–21.85), and also between birth by caesarean section and MIH (OR = 2.9; CI = 1.2–6.9). There was no association between prematurity and MIH.


Peripartum events such as hypoxia during birth or delivery by caesarean section are suggested to be risk factors for the occurrence of MIH in this population.


Molar-incisor hypomineralisation Peripartum events Hypoxia Caesarean section 



We would like to express our gratitude to Dr Béatrice Richard and Frédéric Santos for their contribution to this study. The authors would like to thank Dr. Marlies Elfrink for her critical review of the manuscript. We thank the anonymous reviewers.

Compliance with ethical standards

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. For this retrospective study, oral informed consent was obtained from all individual participants included in the study.

Conflict of interest

Authors declare that they have no conflict of interest.


  1. American College of Obstetricians and Gynecologists Committee Opinion No 579: Definition of term pregnancy. Obstet Gynecol. 2013;122(5):1139–40.Google Scholar
  2. Ahmadi R, Ramazani N, Nourinasab R. Molar incisor hypomineralization: a study of prevalence and etiology in a group of Iranian children. Iran J Pediatr. 2012;22(2):245–51.PubMedPubMedCentralGoogle Scholar
  3. Alaluusua S. Aetiology of molar-incisor hypomineralisation: a systematic review. Eur Arch Paediatr Dent. 2010;11(2):53–8.CrossRefPubMedGoogle Scholar
  4. Apgar V. A proposal for a new method of evaluation of the newborn infant. Curr Res Anesth Analg. 1953;32(4):260–7.PubMedGoogle Scholar
  5. Brogardh-Roth S, Matsson L, Klingberg G. Molar-incisor hypomineralization and oral hygiene in 10- to-12-year-old Swedish children born preterm. Eur J Oral Sci. 2011;119(1):33–9.CrossRefPubMedGoogle Scholar
  6. Casey BM, McIntire DD, Leveno KJ. The continuing value of the Apgar score for the assessment of newborn infants. N Engl J Med. 2001;344(7):467–71.CrossRefPubMedGoogle Scholar
  7. Crombie FA, Manton DJ, Weerheijm KL, Kilpatrick NM. Molar incisor hypomineralization: a survey of members of the Australian and New Zealand Society of Paediatric Dentistry. Aust Dent J. 2008;53(2):160–6.CrossRefPubMedGoogle Scholar
  8. Cyna AM, Andrew M, Emmett RS, Middleton P, Simmons SW. Techniques for preventing hypotension during spinal anaesthesia for caesarean section. Cochrane Database Syst Rev. 2006;18(4):CD002251.Google Scholar
  9. da Costa-Silva CM, Jeremias F, de Souza JF, et al. Molar incisor hypomineralization: prevalence, severity and clinical consequences in Brazilian children. Int J Paediatr Dent. 2010;20(6):426–34.CrossRefPubMedGoogle Scholar
  10. Dietrich G, Sperling S, Hetzer G. Molar incisor hypomineralisation in a group of children and adolescents living in Dresden (Germany). Eur J Paediatr Dent. 2003;4(3):133–7.PubMedGoogle Scholar
  11. Elfrink ME, Veerkamp JS, Aartman IH, Moll HA, Ten Cate JM. Validity of scoring caries and primary molar hypomineralization (DMH) on intraoral photographs. Eur Arch Paediatr Dent. 2009;10(Suppl 1):5–10.CrossRefPubMedGoogle Scholar
  12. Elfrink MEC, Ghanim A, Manton DJ, Weerheijm KL. Standardised studies on molar incisor hypomineralisation (MIH) and hypomineralised second primary molars (HSPM): a need. Eur Arch Paediatr Dent. 2015;16(3):247–55.CrossRefPubMedGoogle Scholar
  13. Fagrell TG, Ludvigsson J, Ullbro C, Lundin SA, Koch G. Aetiology of severe demarcated enamel opacities–an evaluation based on prospective medical and social data from 17,000 children. Swed Dent J. 2011;35(2):57–67.PubMedGoogle Scholar
  14. Fagrell TG, Salmon P, Melin L, Noren JG. Onset of molar-incisor hypomineralization (MIH). Swed Dent J. 2013;37(2):61–70.PubMedGoogle Scholar
  15. Finster M, Wood M. The Apgar score has survived the test of time. Anesthesiology. 2005;102(4):855–7.CrossRefPubMedGoogle Scholar
  16. Fogel I, Pinchuk I, Kupferminc MJ, Lichtenberg D, Fainaru O. Oxidative stress in the fetal circulation does not depend on mode of delivery. Am J Obstet Gynecol. 2005;193(1):241–6.CrossRefPubMedGoogle Scholar
  17. Ghanim A, Manton D, Bailey D, Marino R, Morgan M. Risk factors in the occurrence of molar-incisor hypomineralization amongst a group of Iraqi children. Int J Paediatr Dent. 2013;23(3):197–206.CrossRefPubMedGoogle Scholar
  18. Ghanim A, Morgan M, Marino R, Bailey D, Manton D. Molar-incisor hypomineralisation: prevalence and defect characteristics in Iraqi children. Int J Paediatr Dent. 2011;21(6):413–21.CrossRefPubMedGoogle Scholar
  19. Gibbons L, Belizán JM, Lauer JA, et al. The global numbers and costs of additionally needed and unnecessary caesarean sections performed per year: overuse as a barrier to universal coverage, World Health Report (2010), Background Paper No. 30. Geneva: World Health Organization; 2010.Google Scholar
  20. Guergolette RP, Dezan CC, Frossard WT, et al. Prevalence of developmental defects of enamel in children and adolescents with asthma. J Bras Pneumol. 2009;35(4):295–300.CrossRefPubMedGoogle Scholar
  21. Hansen AK, Wisborg K, Uldbjerg N, Henriksen TB. Risk of respiratory morbidity in term infants delivered by elective caesarean section: cohort study. BMJ. 2008;336(7635):85–7.CrossRefPubMedGoogle Scholar
  22. Inanc F, Kilinc M, Kiran G, et al. Relationship between oxidative stress in cord blood and route of delivery. Fetal Diagn Ther. 2005;20(5):450–3.CrossRefPubMedGoogle Scholar
  23. Jälevik B. Prevalence and diagnosis of molar-incisor-hypomineralisation (MIH): a systematic review. Eur Arch Paediatr Dent. 2010;11(2):59–64.CrossRefPubMedGoogle Scholar
  24. Jälevik B, Dietz W, Noren JG. Scanning electron micrograph analysis of hypomineralized enamel in permanent first molars. Int J Paediatr Dent. 2005;15(4):233–40.CrossRefPubMedGoogle Scholar
  25. Jälevik B, Klingberg GA. Dental treatment, dental fear and behaviour management problems in children with severe enamel hypomineralization of their permanent first molars. Int J Paediatr Dent. 2002;12(1):24–32.PubMedGoogle Scholar
  26. Jasulaityte L, Weerheijm KL, Veerkamp JS. Prevalence of molar-incisor-hypomineralisation among children participating in the Dutch National Epidemiological Survey (2003). Eur Arch Paediatr Dent. 2008;9(4):218–23.CrossRefPubMedGoogle Scholar
  27. Jedeon K, De la Dure-Molla M, Brookes SJ, et al. Enamel defects reflect perinatal exposure to bisphenol A. Am J Pathol. 2013;183(1):108–18.CrossRefPubMedPubMedCentralGoogle Scholar
  28. Kuscu OO, Sandalli N, Dikmen S, et al. Association of amoxicillin use and molar incisor hypomineralization in piglets: visual and mineral density evaluation. Arch Oral Biol. 2013;58(10):1422–33.CrossRefPubMedGoogle Scholar
  29. Laisi S, Ess A, Sahlberg C, et al. Amoxicillin may cause molar incisor hypomineralization. J Dent Res. 2009;88(2):132–6.CrossRefPubMedGoogle Scholar
  30. Lygidakis NA, Dimou G, Marinou D. Molar-incisor-hypomineralisation (MIH). A retrospective clinical study in Greek children. II. Possible medical aetiological factors. Eur Arch Paediatr Dent. 2008;9(4):207–17.CrossRefPubMedGoogle Scholar
  31. Muratbegovic A, Markovic N. Ganibegovic Selimovic M. Molar incisor hypomineralisation in Bosnia and Herzegovina: aetiology and clinical consequences in medium caries activity population. Eur Arch Paediatr Dent. 2007;8(4):189–94.CrossRefPubMedGoogle Scholar
  32. Pitiphat W, Luangchaichaweng S, Pungchanchaikul P, Angwaravong O, Chansamak N. Factors associated with molar incisor hypomineralization in Thai children. Eur J Oral Sci. 2014;122(4):265–70.CrossRefPubMedGoogle Scholar
  33. Soviero V, Haubek D, Trindade C, Da Matta T, Poulsen S. Prevalence and distribution of demarcated opacities and their sequelae in permanent 1st molars and incisors in 7- to 13-year-old Brazilian children. Acta Odontol Scand. 2009;67(3):170–5.CrossRefPubMedGoogle Scholar
  34. Weerheijm KL. Molar incisor hypomineralization (MIH): clinical presentation, aetiology and management. Dent Update. 2004;31(1):9–12.PubMedGoogle Scholar
  35. Weerheijm KL, Jälevik B, Alaluusua S. Molar-incisor hypomineralisation. Caries Res. 2001;35(5):390–1.CrossRefPubMedGoogle Scholar
  36. Weerheijm KL, Duggal M, Mejare I, et al. Judgement criteria for molar incisor hypomineralisation (MIH) in epidemiologic studies: a summary of the European meeting on MIH held in Athens, 2003. Eur J Paediatr Dent. 2003;4(3):110–3.PubMedGoogle Scholar
  37. Whatling R, Fearne JM. Molar incisor hypomineralization: a study of aetiological factors in a group of UK children. Int J Paediatr Dent. 2008;18(3):155–62.CrossRefPubMedGoogle Scholar

Copyright information

© European Academy of Paediatric Dentistry 2016

Authors and Affiliations

  1. 1.Univ. de BordeauxUFR des Sciences OdontologiquesBordeaux CedexFrance
  2. 2.Univ. de Bordeaux, PACEA, UMR 5199PessacFrance
  3. 3.Melbourne Dental SchoolUniversity of MelbourneMelbourneAustralia

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