European Archives of Paediatric Dentistry

, Volume 14, Issue 6, pp 411–416 | Cite as

Case report: Macrodont mandibular second premolars, a hereditary dental anomaly

  • A. Kyriazidou
  • D. Haider
  • C. Mason
  • S. Parekh
  • A. Bloch-ZupanEmail author
Case Report



Macrodontia or megadontia is a rare dental anomaly that refers to teeth that appear larger than normal. Generalised macrodontia may be associated with certain medical conditions and syndromes. Isolated macrodontia involves single teeth, might be the result of teeth fusion and is mainly seen in the incisor area.

Case reports

This paper describes two unrelated cases presenting with bilateral macrodont second lower premolars and the treatment provided. One case demonstrated the anomaly in both the patient and his father.


This case report suggests for the first time in the literature the genetic aetiology and heritability, as a possible autosomal dominant trait, of this rare dental anomaly.


Macrodontia Premolars Teeth Genetics Dental anomalies 



This work was supported by a grant from API, 2009–2012, Hôpitaux Universitaires de Strasbourg, “development of the oral cavity: from gene to clinical phenotype in Human” and IFRO (Institut Français pour la Recherche Odontologique). We thank all patients and families who collaborated in this work, and all physicians, dentists involved in the care of these patients.


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Copyright information

© European Academy of Paediatric Dentistry 2013

Authors and Affiliations

  • A. Kyriazidou
    • 1
    • 2
  • D. Haider
    • 2
  • C. Mason
    • 2
  • S. Parekh
    • 1
    • 2
  • A. Bloch-Zupan
    • 1
    • 3
    • 4
    • 5
    Email author
  1. 1.Eastman Dental InstituteUniversity College of LondonLondonUK
  2. 2.Dental and Maxillofacial DepartmentGreat Ormond Street HospitalLondonUK
  3. 3.Faculty of DentistryUniversity of StrasbourgStrasbourgFrance
  4. 4.Reference Centre for Orodental Manifestations of Rare Diseases, Pôle de Médecine et Chirurgie Bucco-DentairesHôpitaux Universitaires de Strasbourg (HUS)StrasbourgFrance
  5. 5.Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Centre Européen de Recherche en Biologie et en Médecine (CERBM), Centre National de la Recherche Scientifique (UMR 7104), Institut National de la Santé et de la Recherche Medicale (U 964), Université de StrasbourgIIIkirchFrance

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