Head-to-head comparison between 18F-FDG PET/CT and PET/MRI in breast cancer
- 60 Downloads
The aim of the present review is to assess the diagnostic performance of PET/CT and PET/MRI in breast cancer patients, by a head-to-head comparison.
Materials and methods
Two reviewers conducted the literature search, study inclusion and data extraction in duplicate. A literature search for studies on a head-to-head comparison between PET/CT and PET/MRI in breast cancer patients was carried out. MEDLINE databases, such as PubMed and Scopus were consulted using the following keywords: “PET/CT” AND “PET/MRI” AND “breast cancer”. Data about the diagnostic accuracy was collected, if available, in terms of sensitivity, specificity and accuracy.
Between 2014 and 2018, 8 articles were available about the head-to-head comparison between PET/CT and PET/MRI in breast cancer patients. PET/CT has a lower sensitivity for the detection of contralateral breast cancer and bone metastasis as compared to PET/MRI. PET/MRI and PET/CT has a similar diagnostic accuracy for the detection of axillary, internal mammary and mediastinal lymph node involvement. Semiquantitative parameters by PET/MRI are higher than those computed by PET/CT, but a strong organ-specific correlation between them was found.
PET/MRI has some advantages in breast cancer, being able to detect more primary and skeletal/non-skeletal distant metastases, as compared to PET/CT, thanks to the advantages from the combined MRI.
KeywordsPET/CT PET/MRI FDG Data accuracy Comparative study
The authors are thankful to the Department of Nuclear Medicine, IRCCS San Raffaele Scientific Institute, Milan, Italy for providing representative images of PET/CT and PET/MRI in breast cancer.
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
Human and animals rights
This article does not contain any studies with human participants or animals performed by any of the authors.
For this type of study formal consent is not required.
- 6.Evangelista L, Baretta Z, Vinante L, Bezzon E, De Carolis V, Cervino AR et al (2012) Comparison of 18F-FDG positron emission tomography/computed tomography and computed tomography in patients with already-treated breast cancer: diagnostic and prognostic implications. Q J Nucl Med Mol Imaging 56:375–384Google Scholar
- 9.Grueneisen J, Beiderwellen K, Heusch P, Gratz M, Schulze-Hagen A, Heubner M et al (2014) Simultaneous positron emission tomography/magnetic resonance imaging for whole-body staging in patients with recurrent gynecological malignancies of the pelvis: a comparison to whole-body magnetic resonance imaging alone. Invest Radiol 49:808–815CrossRefGoogle Scholar
- 18.Grueneisen J, Nagarajah J, Buchbender C, Hoffmann O, Schaarschmidt BM, Poeppel T et al (2015) Positron emission tomography/magnetic resonance imaging for local tumor staging in patients with primary breast cancer: a comparison with positron emission tomography/computed tomography and magnetic resonance imaging. Invest Radiol 50:505–513CrossRefGoogle Scholar