Clinical and Translational Imaging

, Volume 7, Issue 1, pp 45–60 | Cite as

PET in brain tumors

  • Davide DonnerEmail author
  • Umberto Rozzanigo
  • Dante Amelio
  • Silvio Sarubbo
  • Daniele Scartoni
  • Lorena Picori
  • Maurizio Amichetti
  • Franco Chioffi
  • Franca Chierichetti
Pictorial Essay
Part of the following topical collections:
  1. Neuroimaging



The aim of this Pictorial Essay is to illustrate the metabolic aspect of PET (positron emission tomography) imaging in relation to conventional and advanced MR (magnetic resonance) of brain neoplasms.


10 patients, who performed PET–CT with amino acid tracers and/or FDG were selected from a series of more than 250 cases from a single institution. The selection was made to illustrate and discuss each of the indications reported in the European guidelines. Fusion imaging was obtained merging PET–CT with MR T1-CE (contrast enhanced) and/or T2/FLAIR sequences. The SUVmax of the lesion and the SUVmax lesion to SUVmax background ratio were evaluated. The lesion uptake was also assessed using a five-point visual scale with a range from − 2 to + 2 in relation to basal ganglia uptake. The Hospital Information System (HIS) and the proton therapy data archives have been used for clinical history. For each case, the critical issues were described and the physiopathological correlations were provided to explain the imaging findings.


The complexity of illustrated cases demonstrates the need for a multidisciplinary board evaluation to reach a more accurate diagnosis.


Brain lesions Differential diagnosis PET–CT imaging Advanced MR 


Compliance with ethical standards

Conflict of interest

All authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.


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Copyright information

© Italian Association of Nuclear Medicine and Molecular Imaging 2018

Authors and Affiliations

  1. 1.Nuclear Medicine DepartmentSanta Chiara Hospital, APSS TrentoTrentoItaly
  2. 2.Radiology DepartmentSanta Chiara Hospital, APSS TrentoTrentoItaly
  3. 3.Proton TherapyAPSS TrentoTrentoItaly
  4. 4.NeurosurgerySanta Chiara Hospital, APSS TrentoTrentoItaly

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