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High Blood Pressure & Cardiovascular Prevention

, Volume 25, Issue 4, pp 417–420 | Cite as

Lowering Blood Pressure with the Combination of a Sodium-Glucose Cotransporter 2 Inhibitor and a Glucagon-like Peptide-1 Receptor Agonist in Type 2 Diabetic Patients: A Clinical Evidence

  • José Carlos Arévalo-Lorido
  • Juana Carretero Gómez
  • Ricardo Gómez Huelgas
  • Dolores García de Lucas
  • Lourdes Mateos Polo
  • José Manuel Varela Aguilar
  • Javier Ena Muñoz
Short Communication
  • 27 Downloads

Abstract

Introduction

Patients with type 2 diabetes mellitus (T2DM) often have numerous cardiovascular risk factors, among which hypertension.

Aim

To evaluate the blood pressure variations among patients treated with a combination of a sodium-glucose cotransporter 2 inhibitor (iSGLT-2) and a glucagon-like peptide-1 receptor agonist (GLP-1ra).

Methods

We analyze 17 patients treated with this combination to quantify the changes on blood pressure by ambulatory blood pressure monitoring at baseline and at three and 6 months follow-up.

Results

We observed a decrease of HbA1c levels (p = 0.004) at six months follow-up, a decrease in mean 24 h systolic blood pressure [from 124 (11) mmHg to 123 (4.75) mmHg, p = 0.04] and in both, mean waking and sleeping systolic blood pressure, being greater the reduction in the sleeping time [118 (20) mmHg to 111 (20) mmHg, p = 0.004].

Conclusion

The effect of a combination therapy of an iSGLT-2 and a GLP-1ra on blood pressure in a real-world setting, may have summative effects especially in SBP.

Keywords

Ambulatory blood pressure monitoring Diabetes Glucagon-like peptide-1 receptor agonist Sodium-glucose cotransporter 2 inhibitor 

Notes

Compliance with Ethical Standards

Conflict of interest

The authors declare not having conflict of interest. Boehringer Ingelheim, ASTRA and JANSSEN laboratories supported the online database of this registry.

Ethical standards

The study has been approved by the appropriate institutional and/or national research ethics committee (Hospital Universitario de Málaga) and has been performed in accordance with the ethical standards as laid down in the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Copyright information

© Springer Nature Switzerland AG 2018

Authors and Affiliations

  • José Carlos Arévalo-Lorido
    • 1
  • Juana Carretero Gómez
    • 1
  • Ricardo Gómez Huelgas
    • 2
  • Dolores García de Lucas
    • 3
  • Lourdes Mateos Polo
    • 4
  • José Manuel Varela Aguilar
    • 5
  • Javier Ena Muñoz
    • 6
  1. 1.Internal Medicine DepartmentZafra County HospitalZafraSpain
  2. 2.Internal Medicine DepartmentUniversity Hospital of MálagaMálagaSpain
  3. 3.Internal Medicine Department“Costa del sol” HospitalMarbellaSpain
  4. 4.Internal Medicine DepartmentUniversity Hospital of SalamancaSalamancaSpain
  5. 5.Internal Medicine DepartmentUniversity Hospital “Virgen del Rocio”SevillaSpain
  6. 6.Internal Medicine Department“Marina Baixa” HospitalLa Vila JoiosaSpain

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