- 76 Downloads
An event is serious (based on the ICH definition) when the patient outcome is:
* congenital anomaly
* other medically important event
In a retrospective single‐center analysis of pediatric patients, a 13-year-old girl (patient 1) developed cytomegalovirus retinitis (CMVR) during treatment with busulfan, cyclophosphamide, melphalan, ciclosporin, methotrexate, antithymocyte globulin, methylprednisolone and budesonide for relapsed acute myeloid leukemia (AML) and a 10-year-old girl (patient 2) developed CMVR during treatment with prednisone, fludarabine, treosulfan, thiotepa, ciclosporin, methotrexate, antithymocyte globulin, methylprednisolone for acute lymphoblastic leukemia (ALL).
Patient 1: The CMV‐seropositive girl with relapsed AML M2 bearing the t(8;21) translocation was scheduled for allogeneic hematopoietic stem cell transplantation (HSCT) in second hematological remission. She received conditioning...
- Zollner SK, et al. Cytomegalovirus retinitis in children and adolescents with acute leukemia following allogeneic hematopoietic stem cell transplantation. Transplant Infectious Disease 21: No. 5, Oct 2019. Available from: URL: http://doi.org/10.1111/tid.13089 - Germany