Reactions Weekly

, Volume 1778, Issue 1, pp 255–255 | Cite as

Interferon and antivirals

Graft versus host disease and diarrhoea: 2 case reports
Case report
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An event is serious (based on the ICH definition) when the patient outcome is:

  • * death

  • * life-threatening

  • * hospitalisation

  • * disability

  • * congenital anomaly

  • * other medically important event

In a case series of 2 patients, two men aged 56 years and 64 years were described, who developed graft versus host disease (GVHD) following administration of ledipasvir/sofosbuvir or ribavirin and unspecified interferon for hepatitis C virus infection. Additionally, the 56-year-old man also developed diarrhoea following administration of immunosuppressant drug therapy with mycophenolate mofetil [dosages, routes, times to reactions onsets not stated; not all outcomes stated].

Case 1: The 56-year-old man underwent orthotropic liver transplantation for decompensated cirrhosis secondary to hepatitis C virus (HCV). His maintenance immunosuppressant drug therapy included mycophenolate mofetil along with concurrent tacrolimus. The donor was cytomegalovirus seropositive. One month...


  1. Advani SD, et al. Two Cases and a Review of Graft-Versus-Host Disease and the Role of Hepatitis C Treatment in Liver Transplant Patients. Progress in Transplantation (Aliso Viejo, Calif.) 28: 267-270, No. 3, Sep 2018. Available from: URL: - USACrossRefGoogle Scholar

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© Springer International Publishing AG 2019

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