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, Volume 1770, Issue 1, pp 162–162 | Cite as

Endostatin/fluorouracil/nedaplatin

Haematologic toxicities and elevations in creatinine and ALT: 3 case reports
Case report
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A case series described three patients (2 men and 1 woman) aged 36−46 years, who experienced various haematological toxicities, including decrease in WBCs, decrease in neutrophils, anaemia, decrease in platelets, increase in ALT and increase in creatinine during treatment with endostatin, fluorouracil and nedaplatin for refractory nasopharyngeal carcinoma (NPC).

Case 1: A 44-year-old man was diagnosed with stage III NPC (T3N1M0) in August 2013, with a viral load (Epstein-Barr virus, EBV DNA) of 9.8 × 102 copies/mL. He subsequently underwent two cycles of cisplatin [DDP] 75 mg/m2, once every 3 weeks alongside intensity-modulated radiation therapy (IMRT). However, during follow-up in June 2014, he was found to have tumour recurrence in the level II lymph nodes in the left neck. His viral load also increased in November 2014; therefore, he started receiving lobaplatin and fluorouracil [5-fluorouracil] for 4 cycles, alongside concurrent radiation therapy. He also received cytokine-induced...

Reference

  1. Chen C, et al. Recombined humanized endostatin (Endostar) intravenous infusion in the treatment of refractory nasopharyngeal carcinoma: Three case reports. Medicine 98: No. 32, Aug 2019. Available from: URL: http://doi.org/10.1097/MD.0000000000016592 - China

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© Springer International Publishing AG 2019

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