Reactions Weekly

, Volume 1769, Issue 1, pp 307–307 | Cite as

Multiple drugs

Lack of efficacy: case report
Case report
Author Information

An event is serious (based on the ICH definition) when the patient outcome is:

  • * death

  • * life-threatening

  • * hospitalisation

  • * disability

  • * congenital anomaly

  • * other medically important event

A 58-year-old man exhibited lack of efficacy during treatment with antimicrobials including ceftriaxone, gentamicin, clindamycin, linezolid, meropenem and piperacillin/tazobactam for Edwardsiella tarda bacteraemia, and during treatment with dobutamine, vancomycin, vasopressin, norepinephrine and phenylephrine for haemodynamic instability. Additionally, he did not respond to salvage therapy including ascorbic acid, hydrocortisone, thiamine and immune globulin [not all routes and dosages stated].

The man, who had a history of untreated hepatitis C, presented to the emergency department with a 2 days history of left hand pain and swelling attributed to a suspected catfish sting or stick with a contaminated fish hook. A dialysis catheter was inserted in the emergency department for...


  1. Morrisette T, et al. Edwardsiella tarda Bacteremia in Untreated Hepatitis C: Alterations in Antimicrobial Therapy for a Pan-Susceptible Pathogen in a Critically Ill Patient. American Journal of Therapeutics 26: e530-e533, No. 4, Jul-Aug 2019. Available from: URL: - USA

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© Springer International Publishing AG 2019

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