Reactions Weekly

, Volume 1769, Issue 1, pp 213–214 | Cite as


Cystic bleb: 12 case reports
Case report

In a prospective, single-centre, interventional case series of 12 patients (aged 36−84 years) with late-onset bleb leak between August 2014 and September 2017, 6 men and 6 women [ages at reaction onsets not stated] were described, who developed cystic bleb following treatment with mitomycin [mitomycin C] or fluorouracil [5-fluorouracil] for glaucoma filtration surgery [routes, times to reactions onsets and outcomes not stated; not all dosages stated].

Patient 1: A woman had primary open-angle glaucoma (POAG) of the left eye. In August 2014, she underwent ExPress shunt with mitomycin 0.4 mg/mL for 3 minutes. However, she developed a cystic bleb secondary to mitomycin. 0.4 years after surgery, she was diagnosed with cystic bleb leak. She was treated with chloramphenicol. At the age of 84 years, she underwent collagen crosslinking (CXL) procedure after 4 days from the diagnosis of the cystic bleb leak. Four weeks later, the bleb leak stopped. No leaking was found until the last follow-up...


  1. Cai Y, et al. Prospective study on a novel treatment for leaking cystic bleb: Efficacy and safety of collagen crosslinking. Clinical and Experimental Ophthalmology 47: 749-756, No. 6, Aug 2019. Available from: URL: - Hong KongPubMedGoogle Scholar

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© Springer International Publishing AG 2019

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