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An event is serious (based on the ICH definition) when the patient outcome is:
* congenital anomaly
* other medically important event
A 38-year-old man exhibited lack of efficacy during treatment with norepinephrine for haemodynamic instability in
life-threatening acute anaerobic septic shock triggered by descending necrotising mediastinitis.
The man was admitted in an emergency department in a critical condition. His symptoms had started following physical exercise 2 weeks prior to the presentation. Initially, he was diagnosed with tonsillitis, which was complicated with several retro-pharyngeal abscesses. He had received unspecified first-line antibiotics; however, the treatment had failed. Eventually, his clinical condition had deteriorated and therefore, he was referred to the current hospital. Clinical examination showed the following: heart rate 130 beats/minute, BP 100/70mm Hg, Glasgow coma scale 10, a...
- Popevski D, et al. Continuous venovenous hemodiafiltration using cytokine-adsorbing hemofilters as adjuvant therapy for anaerobic descending necrotizing mediastinitis: A case report. Journal of Medical Case Reports 13: 205, No. 1, 5 Jul 2019. Available from: URL: http://doi.org/10.1186/s13256-019-2123-7 - Macedonia