Reactions Weekly

, Volume 1766, Issue 1, pp 228–228 | Cite as


Lack of efficacy: case report
Case report
Author Information

An event is serious (based on the ICH definition) when the patient outcome is:

  • * death

  • * life-threatening

  • * hospitalisation

  • * disability

  • * congenital anomaly

  • * other medically important event

A 38-year-old man exhibited lack of efficacy during treatment with norepinephrine for haemodynamic instability in

life-threatening acute anaerobic septic shock triggered by descending necrotising mediastinitis.

The man was admitted in an emergency department in a critical condition. His symptoms had started following physical exercise 2 weeks prior to the presentation. Initially, he was diagnosed with tonsillitis, which was complicated with several retro-pharyngeal abscesses. He had received unspecified first-line antibiotics; however, the treatment had failed. Eventually, his clinical condition had deteriorated and therefore, he was referred to the current hospital. Clinical examination showed the following: heart rate 130 beats/minute, BP 100/70mm Hg, Glasgow coma scale 10, a...


  1. Popevski D, et al. Continuous venovenous hemodiafiltration using cytokine-adsorbing hemofilters as adjuvant therapy for anaerobic descending necrotizing mediastinitis: A case report. Journal of Medical Case Reports 13: 205, No. 1, 5 Jul 2019. Available from: URL: - Macedonia

Copyright information

© Springer International Publishing AG 2019

Personalised recommendations