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An event is serious (based on the ICH definition) when the patient outcome is:
* congenital anomaly
* other medically important event
A 22-month-old boy developed aggravation of chickenpox and polymicrobial Fournier's gangrene following treatment with naproxen for fever.
The boy presented to hospital with the symptoms of chickenpox. His sister had presented 2 weeks prior to the onset of his symptoms. The vaccination regimen was incomplete. Prior to the presentation, he had received naproxen [route and dosage not stated] along with paracetamol, which was followed by improvement for 2 days. However, 3 days before presentation, vesicular and papular lesions appeared on his back and head, which spread over his total body surface, and subsequently changed into scabby lesions. One day later, the lesions in his genital area increased in volume. These lesions started in the right inguinal region, which were painful,...
- De Lara huerta J, et al. Complicated chickenpox with Fournier gangrene associated with nonsteroidal anti-inflammatory drugs (NSAIDS) use in a child. Enfermedades Infecciosas y Microbiologia 38: 93-98, No. 3, 2018. Available from: URL: https://www.medigraphic.com/cgi-bin/new/resumenI.cgi?IDARTICULO=86497 [Spanish; summarised from a translation] - Mexico