Reactions Weekly

, Volume 1766, Issue 1, pp 208–208 | Cite as

Multiple drugs

Various toxicities: 9 case reports
Case report
Author Information

An event is serious (based on the ICH definition) when the patient outcome is:

  • * death

  • * life-threatening

  • * hospitalisation

  • * disability

  • * congenital anomaly

  • * other medically important event

  • * Drug interaction

In a cross-sectional study of 89 patients, 9 patients (including two male patients) [ages not stated; not all sexes stated] were described, who developed metformin-associated lactic acidosis, aggravated metformin associated lactic acidosis, fatigue, lower stamina, hypoglycaemia, erratic blood sugar, gastric pain, ischaemia, angina pain or severe muscular pain following concurrent administration of aloe vera, andrographis paniculata, cefalexin, cimentidine, diclofenac, gemfibrozil, glibenclamide, mangifera, metformin, omeprazole, propranolol or repaglinide [dosages, routes, duration of treatments to reactions onsets and outcomes not stated; not all indications stated].

Case 1: The patient developed metformin-associated lactic acidosis following concurrent...


  1. Agrawal A, et al. Necessity of dosage adjustment in concurrent drug therapy in diabetes: Evidences from a cross -sectional study. International Journal of Research in Ayurveda and Pharmacy 10: 109-111, No. 2, Mar 2019. Available from: URL: - India

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