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A case series described three men aged 23−37 years, who developed serious aggressive behaviour and worsening of pre-existing psychiatric symptoms (paradoxical reaction) while receiving antipsychotic therapy with olanzapine. One of these patients, a 37-year-old man, additionally developed extrapyramidal symptoms due to antipsychotic therapy with aripiprazole [routes not stated; not all times to reactions onsets clearly stated].
Case 1: A 37-year-old man presented with symptoms of depression for 4 weeks prior to admission. Subsequently, he started receiving sertraline alongside olanzapine 10mg following the diagnosis of severe depression. However, 7 days later, he experienced epileptic seizures and a decline in cognitive functioning. He received corrective therapy; however, he exhibited severe respiratory failure and heart failure, with persistent psychiatric symptoms, including delusions, visual and auditory hallucinations. His psychiatric symptoms did not improve with aripiprazole...
- Yang P, et al. Effect of clozapine on anti-N-methyl-D-aspartate receptor encephalitis with psychiatric symptoms: A series of three cases. Frontiers in Neuroscience 13: 09 Apr 2019. Available from: URL: http://doi.org/10.3389/fnins.2019.00315 - China