An event is serious (based on the ICH definition) when the patient outcome is:
* congenital anomaly
* other medically important event
An approximately 57-year-old woman developed dopamine dysregulation syndrome following abuse of levodopa/carbidopa for parkinsonism.
The woman, who was diagnosed with parkinsonism at the age of 52 years, started receiving levodopa/carbidopa [carbidopa/levodopa] 25/100 three tablets daily. The frequency of levodopa/carbidopa was changed to twice daily at a 4-month follow-up. Subsequently, she returned to work with improved condition and gained 3 pounds of weight. However, she was unable to work after 10 months of the initial presentation. A wearing off effect of daily three tablets of levodopa/carbidopa was noted, and she gained 6 pounds of weight. The wearing off effect led to worsening of the parkinsonism with weight gain of 132 pounds and some symptoms of depression. The...
- Stacy M. Treatment of dopamine dysregulation syndrome and impulse control disorders in Parkinson's disease. Current Clinical Neurology - Monographs : 125-127, 2019. Available from: URL: http://doi.org/10.1007/978-3-319-97897-0_30 - USA