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, Volume 1761, Issue 1, pp 193–193 | Cite as


Progressive multifocal leukoencephalopathy, accrued cerebral swelling and use of prescription corticosteroids without prescription: case report
Case report
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An event is serious (based on the ICH definition) when the patient outcome is:

  • * death

  • * life-threatening

  • * hospitalisation

  • * disability

  • * congenital anomaly

  • * other medically important event

A 41-year-old man developed fatal progressive multifocal leukoencephalopathy (PML) and accrued cerebral swelling during treatment with natalizumab, dexamethasone and prednisolone [dosages not stated; not all route stated] for multiple sclerosis. Additionally, he had used dexamethasone and prednisolone without prescription.

The man was diagnosed with multiple sclerosis in May 2006. Subsequently, a pulse therapy with corticosteroids was conducted. In 2012, he was initiated on natalizumab as a participant in the clinical study RusTis. He received 10 infusion of natalizumab during this period. From August 2016 to December 2017, he received 17 infusions. During flair-up, he was prescribed corticosteroid infusions at home. Since 2016, he independently took IM dexamethasone and oral...


  1. Zakharova MN, et al. [The case-report of progressive multifocal leukoencephalopathy in a patient with multiple sclerosis treated with natalizumab]. [Russian]. Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova 118: 107-109, No. 8, 2018. Available from: URL: [Russian; summarised from a translation] - Russia

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© Springer International Publishing AG 2019

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