- 11 Downloads
An event is serious (based on the ICH definition) when the patient outcome is:
* congenital anomaly
* other medically important event
A 26-year-old woman developed multiple cervical root resorption following treatment with cisplatin, etoposide and bleomycin for ovarian cancer [routes not stated].
The woman, who was diagnosed with ovarian cancer at the age of 16 years, had received chemotherapy with five cycles of cisplatin 500 mg/m2 (20 mg/m2 daily for 5 daysin a cycle for 5 cycles), etoposide 2500 mg/m2 (100 mg/m2 daily for 5 days in a cycle for 5 cycles) and bleomycin 390 mg/m2 (30 mg/m2 daily for 3 days in the first 4 cycles and a single dose in the last cycle). Additionally, she had received treatment with triptorelin [Decapeptyl] and cyproterone [Androcur] for first 25 days of treatment. Three months after the initiation of treatment, she presented to the dentist due of increased mobility of 12th...
- Llavayol M, et al. Multiple Cervical Root Resorption in a Young Adult Female Previously Treated with Chemotherapy: A Case Report. Journal of Endodontics 45: 349-353, No. 3, Mar 2019. Available from: URL: http://doi.org/10.1016/j.joen.2018.12.012 - Spain