An event is serious (based on the ICH definition) when the patient outcome is:
* congenital anomaly
* other medically important event
A 65-year-old woman developed Moraxella catarrhalis (M. catarrhalis) bacteraemia associated with infectious endocarditis and vertebral osteomyelitis, and upper respiratory tract infection during treatment with azathioprine for Crohn's disease [duration of treatment to reaction onsets not stated].
The woman was admitted to an emergency department with a 5-week history of progressive fatigue, persistent nausea, diffuse myalgia, intermittent daily high-grade fever, weight loss and night sweats. Additionally, she reported acute worsening of long-standing lower back pain and stiff joints. She had developed sore throat for 2 weeks along with chills and night sweats prior to the onset of current symptoms, due to upper respiratory tract infection. The infection was considered to...
- Maierean SM, et al. Infectious endocarditis and vertebral osteomyelitis caused by Moraxella catarrhalis. BMJ Case Reports 12: e228776, No. 5, 24 May 2019. Available from: URL: http://doi.org/10.1136/bcr-2018-228776 - Romania