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In a case series, 5 patients [4 women and 1 man] aged 50−82 years were described, who developed delusional infestation during treatment with amantadine, entacapone, pergolide, ropinirole or trihexyphenidyl for Parkinson's disease (PD) [routes and durations of treatments to reactions onsets not stated].
Patient 1: An 82-year-old woman developed delusional infestation during treatment with amantadine and pergolide. The woman, who had a history of akinetic-rigid PD for 7 years and melanoma, was hospitalised to a psychiatry unit due to a delusional infestation of her nose with pungent bugs. She had been receiving amantadine 100mg twice daily and pergolide 4.5mg once daily. The motor symptoms were noted to have been poorly controlled, and she had gait instability and falls. She started receiving levodopa/carbidopa [carbidopa/L-dopa], which was subsequently increased. The pergolide therapy was tapered over 1 month and then discontinued. The delusional infestation resolved 2 weeks later. She...
- Davis J L, et al. Delusional Infestation in Parkinson's Disease. Movement Disorders Clinical Practice 4: 111-115, No. 1, Jan-Feb 2017. Available from: URL: http://dx.doi.org/10.1002/mdc3.12352 - USAGoogle Scholar