Reactions Weekly

, Volume 1761, Issue 1, pp 14–14 | Cite as


Disseminated visceral varicella zoster virus infection and lack of efficacy: case report
Case report
Author Information

An event is serious (based on the ICH definition) when the patient outcome is:

  • * death

  • * life-threatening

  • * hospitalisation

  • * disability

  • * congenital anomaly

  • * other medically important event

A 66-year-old woman died due to disseminated visceral varicella zoster virus (VZV) infection following immunosuppressive therapy with everolimus, mycophenolate mofetil and prednisolone. Additionally, she experienced lack of efficacy following treatment with aciclovir for disseminated visceral varicella zoster virus infection [not all routes stated; durations of treatments to reaction onset not stated].

The woman presented with a 4-day history of sharp, left-sided chest pain. She had undergone a deceased donor renal transplantation 2 years earlier for hypertensive nephropathy, with cytomegalovirus serostatus mismatch (donor negative/recipient positive). She had been receiving a standard immunosuppressive regimen comprising everolimus 1.25mg twice daily, prednisolone 5mg...


  1. Loftus MJ, et al. Fatal disseminated visceral varicella zoster virus infection in a renal transplant recipient. Transplant Infectious Disease 21: e13062, No. 3, Jun 2019. Available from: URL: - Australia

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© Springer International Publishing AG 2019

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