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An event is serious (based on the ICH definition) when the patient outcome is:
* congenital anomaly
* other medically important event
In a report, a 50-year-old man and a 44-year-old woman were described, who developed acute angle closure following treatment with topiramate for off-label use for weight loss (1 patient) or prevention of migraine (1 patient) [routes not stated; not all dosages stated].
Case 1 (a 50-year-old man): The man received a single dose of topiramate 50mg for weight loss. Four days later, he presented for eye examination. His right eye examination revealed that the distance vision was fingers count with pinhole 6/48. His left eye vision was 6/36 with pinhole 6/24. He was found to have developed a new myopic shift of -1.50 D. A gonioscopy revealed that the corneal angles were completely closed. Corneas of both the eyes were oedematous. Intraocular pressures in both eyes measured 68mm Hg at...