- 27 Downloads
An event is serious (based on the ICH definition) when the patient outcome is:
* congenital anomaly
* other medically important event
A 56-year-old woman developed lymphoproliferative disorder (LPD) leading to hypercalcaemia during treatment with methotrexate along with off-label use of hydroxychloroquine and mycophenolate mofetil for psoriasis versus psoriatic arthritis [routes not stated].
The woman, who had interstitial pneumonia, Sjogren's syndrome and psoriasis versus psoriatic arthritis, presented with chills, fevers, loss of appetite, dry cough and weight loss for a duration of one month. She also had informed that the non-productive cough had exacerbated within the last 10 days. She was therefore hospitalised. Upon a review of medicinal record, it was revealed that her body temperature was 104°F on the day before this hospitalisation. Additionally, it was also noted that she had been receiving...
- Lee M, et al. Methotrexate-induced iatrogenic immunodeficiency-associated lymphoproliferative disorder causing hypercalcaemia. BMJ Case Reports 12: No. 5, 31 May 2019. Available from: URL: http://doi.org/10.1136/bcr-2018-226633 - USA