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An event is serious (based on the ICH definition) when the patient outcome is:
* congenital anomaly
* other medically important event
In a series, five patients [three men and two women] aged 34−63 years were described, who developed endophthalmitis secondary to bacterial infections with Burkholderia cepacia or Pseudomonas aeruginosa infection following treatment with dimeticone [silicone oil] as an endotamponade which was contaminated with Burkholderia cepacia and Pseudomonas aeruginosa [dosages and routes not stated; not all durations of treatments to reactions onset stated].
Case 1: A 60-year-old woman with a history of retinal detachment in the right eye, had undergone right eye vitrectomy with contaminated dimeticone on 29 April 2011. The retina was completely reattached under dimeticone. After the surgery, by the first day through to the first month she was treated with unspecified steroid and antibiotic...
- Okonkwo ON, et al. Burkholderia cepacia, a cause of post pars plana vitrectomy silicone oil related endophthalmitis: Clinico-pathological presentation and outcome of management. International Journal of Retina and Vitreous 4: 35, No. 1, 2018. Available from: URL: http://doi.org/10.1186/s40942-018-0138-7 - Nigeria